ReviewSeminars in nephrology2020
Uric Acid and Urate in Urolithiasis: The Innocent Bystander, Instigator, and Perpetrator.
Review in Seminars in nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- A holistic guide to effective prevention and treatment for kidney stones: a systematic review exploring anti-urolithiasis approaches.Naunyn-Schmiedeberg's archives of pharmacology · 2026Pooled it
- Stone composition and clinical characteristics of pediatric urolithiasis between Tibetan and non-Tibetan populations in Western China.Pediatric nephrology (Berlin, Germany) · 2026Article
- Association of the uric acid-to-high-density lipoprotein cholesterol ratio with uric acid stones: a single-center retrospective cohort study.Translational andrology and urology · 2026Article
- Article
- Correlation between Running Average of Serum Uric Acid Levels and Clinical Course in Secondary Prevention of Coronary Artery Disease.Internal medicine (Tokyo, Japan) · 2026Article
- Reduced Serum Uric Acid and Albumin Levels in Patients with Migraine: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- The Association and Racial-Ethnic Disparities Between Arthritis and Kidney Stone Disease: A Population Study from 2007 To 2020 US National Health and Nutrition Examination Survey.Journal of racial and ethnic health disparities · 2025Article
- Radiomics application using non-contrast computed tomography for predicting uric acid kidney stones.BMC medical imaging · 2025Article
- In-vitro and in-vivo evaluation for anti-urolithiasis potential of Ficus racemosa L. bark extract in ethylene glycol induced rat model.Urolithiasis · 2025Article
- Fast Detection of Uric Acid in Urine for Early Diagnosis Using THz Polarized Waves.Sensors (Basel, Switzerland) · 2025Article
- Lychee Peel Extract Ameliorates Hyperuricemia by Regulating Uric Acid Production and Excretion in Mice.Current issues in molecular biology · 2025Article
- Serum Uric Acid and Bone Health in Middle-Aged and Elderly Hypertensive Patients: A Potential U-Shaped Association and Implications for Future Fracture Risk.Metabolites · 2025Article
- Causal association of serum vitamin D levels with urolithiasis: a bidirectional two-sample Mendelian randomization study.European journal of nutrition · 2024Article
- Hyperuricemia and its related diseases: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2024Review
- Association of urinary excretion rates of uric acid with biomarkers of kidney injury in patients with advanced chronic kidney disease.PloS one · 2024Article
- Increased risk of chronic kidney disease in uric acid stone formers with high neutrophil-to-lymphocyte ratio.Scientific reports · 2023Article
- Association of serum bicarbonate with the development of kidney stones in patients with chronic kidney disease: a retrospective cohort study.Clinical kidney journal · 2023Article
- Epidemiology of Kidney Stones.Healthcare (Basel, Switzerland) · 2023Review
- Urinary Risk Profile, Impact of Diet, and Risk of Calcium Oxalate Urolithiasis in Idiopathic Uric Acid Stone Disease.Nutrients · 2023Article
- Uric Acid in Parkinson's Disease: What Is the Connection?Movement disorders : official journal of the Movement Disorder Society · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Uric acid is an end product of purine metabolism in human beings. An unusual and still unexplained phenomenon is that higher primates have relatively high uric acid levels in body fluids owing to a combination of absence of degradation and renal retention. The physiologic purpose of high uric acid levels still is enigmatic, but the pathobiologic burden is a variety of crystallopathies owing to the low aqueous solubility of uric acid such as gouty arthritis and acute uric acid nephropathy. In the urinary space, three distinct conditions result from chronic uric acid and/or urate precipitation. The first and most common variety is uric acid urolithiasis. In this condition, urate is a victim of a systemic metabolic disease in which increased acid load to the kidney is coupled with diminished urinary buffer capacity owing to defective ammonium excretion, resulting in titration of urate to its sparingly soluble protonated counterpart, uric acid, and the formation of stones. Uric acid is the innocent bystander of the crime. The second variety is hyperuricosuric calcium urolithiasis, in which uric acid confers lithogenicity via promotion of calcium oxalate precipitation by multiple mechanisms involving soluble, colloidal, and crystalline urate salts. Uric acid is the instigator of the crime. The third and least common condition involves urate as an integral part of the urolith as an ammonium salt driven by high ammonium and high urate concentrations in urine. Here, uric acid is one of the perpetrators of the crime. Both known and postulated pathogenesis of these three types of urolithiasis are reviewed and summarized.
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