Evidence map›Paper›PMID 33678145›Full record

ArticleJournal of toxicology and environmental health. Part A2021

Autoantibodies and cancer among asbestos-exposed cohorts in Western Australia.

Renee N Carey, Jean C Pfau, Marvin J Fritzler, Jenette Creaney, Nicholas de Klerk, Arthur W Bill Musk, Peter Franklin, Nita Sodhi-Berry, Fraser Brims, Alison Reid

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of toxicology and environmental health. Part A, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Renee N CareySchool of Public Health, Curtin University, Bentley, Australia.ORCID 0000-0002-0152-5971
Jean C PfauDepartment of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA.ORCID 0000-0002-1249-7195
Marvin J FritzlerCumming School of Medicine, University of Calgary, Calgary, Canada.ORCID 0000-0003-1652-6608
Jenette CreaneyNational Centre for Asbestos Related Diseases, University of Western Australia, Nedlands, Australia.ORCID 0000-0002-9391-9395
Nicholas de KlerkTelethon Kids Institute, University of Western Australia, Nedlands, Australia.ORCID 0000-0001-9223-0767
Arthur W Bill MuskDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia.ORCID 0000-0003-4730-4645
Peter FranklinSchool of Population and Global Health, University of Western Australia, Nedlands, Australia.ORCID 0000-0002-9983-1212
Nita Sodhi-BerrySchool of Population and Global Health, University of Western Australia, Nedlands, Australia.ORCID 0000-0003-3406-6019
Fraser BrimsDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia.ORCID 0000-0002-6725-7535
Alison ReidSchool of Public Health, Curtin University, Bentley, Australia.ORCID 0000-0002-1202-7150
The University of Western Australia · AUCurtin University · AUMontana State University · USThe Kids Research Institute Australia · AUUniversity of Calgary · CA

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
NCATS NIH HHS UL1 TR002319
6 · The paper itself

Abstract

Asbestos exposure is associated with many adverse health conditions including malignant mesothelioma and lung cancer as well as production of autoantibodies. Autoantibodies may serve as biomarkers for asbestos exposure in patients with cancer, and autoimmune dysfunction has been linked to increased rates of various cancers. The aim of this study was to examine the hypothesis that autoantibodies are more frequent in asbestos-exposed individuals with either lung cancer or mesothelioma than those without these conditions. Asbestos-exposed individuals from Western Australia who had lung cancer (n = 24), malignant mesothelioma (n = 24), or no malignancy (n = 51) were tested for antinuclear autoantibodies (ANA) using indirect immunofluorescence and specific extractable nuclear autoantibodies (ENA) employing a multiplexed addressable laser bead immunoassay. Contrary to the hypothesis, data demonstrated that individuals without malignancy were more likely to be positive for ANA compared to those with cancer. However, autoantibodies to histone and Ro-60 were found to be associated with lung cancer. These results support a possible predictive value for specific autoantibodies in the early detection of lung cancer and/or in our understanding of the role of autoimmune processes in cancer. However, further studies are needed to identify specific target antigens for the antibodies.

Indexed as

AgedAsbestosAutoantibodiesFemaleHumansLung NeoplasmsMaleMesothelioma, MalignantMiddle AgedMiningOccupational ExposureWestern AustraliaAsbestosAutoantibodiesAsbestosautoimmune antibodiescancerexposurelung cancermalignant mesothelioma

Identifiers

PMID33678145
PMCPMC10726378
OpenAlexW3133573625

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.