Evidence map›Paper›PMID 33677970›Full record

ArticleJournal of medicinal chemistry2021

Synthesis, Optimization, and Biological Evaluation of Corrinated Conjugates of the GLP-1R Agonist Exendin-4.

Ian C Tinsley, Tito Borner, MacKenzie L Swanson, Oleg G Chepurny, Sarah A Doebley, Varun Kamat, Ian R Sweet, George G Holz, Matthew R Hayes, Bart C De Jonghe and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Ian C TinsleyDepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.
Tito BornerDepartment of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania 19104, United States.
MacKenzie L SwansonDepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.
Oleg G ChepurnyDepartment of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, United States.
Sarah A DoebleyDepartment of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania 19104, United States.
Varun KamatDepartment of Medicine, University of Washington, Medicine Diabetes Institute, Seattle, Washington 98109, United States.
Ian R SweetDepartment of Medicine, University of Washington, Medicine Diabetes Institute, Seattle, Washington 98109, United States.
George G HolzDepartment of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, United States.
Matthew R HayesDepartment of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States.
Bart C De JongheDepartment of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania 19104, United States.
Robert P DoyleDepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.ORCID 0000-0001-6786-5656
University of Pennsylvania · USSUNY Upstate Medical University · USSyracuse University · USUniversity of Washington · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Neural Mechanisms of Nausea, Vomiting, and Energy DysregulationR01DK112812 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Bart C DE JONGHE, MATTHEW R HAYES · 2017 to 2026
$4.4M
Molecular Basis of Antidiabetogenic Hormone ActionR01DK069575 · NIDDK · UPSTATE MEDICAL UNIVERSITY · PI HOLZ, GEORGE G · 2007 to 2017
$2.9M
Astrocytes mediate GLP-1 effects on energy balanceR01DK115762 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI HAYES, MATTHEW R · 2018 to 2022
$2.8M
Second generation GLP-1 agonists without nausea/emesis side effectsR01DK128443 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DE JONGHE, BART C, DOYLE, ROBERT P · 2021 to 2024
$2.4M
Alpha7 Nicotinic Acetylcholine Receptor Regulation of Glucagon-Like Peptide-1 Incretin Hormone Action.R01DK122332 · NIDDK · UPSTATE MEDICAL UNIVERSITY · PI HOLZ, GEORGE G · 2020 to 2023
$1.6M
Testing Oral Delivery of the Appetite Suppressing Peptide PYY3-36 Through the VitR15DK097675 · NIDDK · SYRACUSE UNIVERSITY · PI DOYLE, ROBERT P · 2013 to 2013
$221k
Astrocytes mediate GLP-1 effects on energy balanceR56DK115762 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI HAYES, MATTHEW R · 2017 to 2017
$211k
NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK069575NIDDK NIH HHS R01 DK112812NIDDK NIH HHS R01 DK115762NIDDK NIH HHS R01 DK122332NIDDK NIH HHS R01 DK128443NIDDK NIH HHS R15 DK097675NIDDK NIH HHS R56 DK115762
6 · The paper itself

Abstract

Corrination is the conjugation of a corrin ring containing molecule, such as vitamin B

Indexed as

Glucagon-Like Peptide-1 Receptor AgonistsAnimalsCells, CulturedCorrinoidsExenatideGlucagon-Like Peptide-1 ReceptorHEK293 CellsHumansHypoglycemic AgentsInsulin SecretionIslets of LangerhansModels, MolecularRatsRats, Sprague-DawleycorrinCorrinoidsExenatideGlucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor AgonistsHypoglycemic Agents

Identifiers

PMID33677970
PMCPMC8279408
OpenAlexW3133914731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.