Evidence map›Paper›PMID 33677964›Full record

ArticleBioconjugate chemistry2021

Peptide Derivatives of Retinylamine Prevent Retinal Degeneration with Minimal Side Effects on Vision in Mice.

Guanping Yu, Song-Qi Gao, Zhiqian Dong, Li Sheng, Da Sun, Ning Zhang, Jianye Zhang, Seunghee Margeivicus, Pingfu Fu, Marcin Golczak and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Advances and therapeutic opportunities in visual cycle modulation.Progress in retinal and eye research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Guanping YuDepartment of Biomedical Engineering, School of Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Song-Qi GaoDepartment of Biomedical Engineering, School of Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Zhiqian DongCenter for Translation Vision Research, Gavin Herbert Eye Institute, Departments of Ophthalmology, Physiology & Biophysics, and Chemistry, University of California, Irvine, California 92697, United States.
Li ShengDepartment of Biomedical Engineering, School of Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Da SunDepartment of Biomedical Engineering, School of Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.ORCID 0000-0003-4170-1981
Ning ZhangDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Jianye ZhangCenter for Translation Vision Research, Gavin Herbert Eye Institute, Departments of Ophthalmology, Physiology & Biophysics, and Chemistry, University of California, Irvine, California 92697, United States.
Seunghee MargeivicusDepartment of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Pingfu FuDepartment of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Marcin GolczakDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Akiko MaedaCenter for Translation Vision Research, Gavin Herbert Eye Institute, Departments of Ophthalmology, Physiology & Biophysics, and Chemistry, University of California, Irvine, California 92697, United States.
Krzysztof PalczewskiCenter for Translation Vision Research, Gavin Herbert Eye Institute, Departments of Ophthalmology, Physiology & Biophysics, and Chemistry, University of California, Irvine, California 92697, United States.ORCID 0000-0002-0788-545X
Zheng-Rong LuDepartment of Biomedical Engineering, School of Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.ORCID 0000-0001-8185-9519
Case Western Reserve University · USUniversity of California, Irvine · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
STRUCTURAL STUDIES OF ARRESTINSR01EY009339 · NEI · UNIVERSITY OF WASHINGTON · PI KISER, PHILIP DAVID, PALCZEWSKI, KRZYSZTOF · 1992 to 2025
$16.0M
Pharmacological Treatment of Retinal DiseasesR24EY021126 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI PALCZEWSKI, KRZYSZTOF · 2010 to 2014
$12.8M
Novel therapies to inhibit Diabetic RetinopathyR24EY024864 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KERN, TIMOTHY S · 2015 to 2019
$8.1M
Use of systems pharmacology to prevent rod and cone photoreceptor degenerationR24EY027283 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2017 to 2021
$7.9M
Regulation of vitamin A metabolism in the eyeR01EY023948 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI GOLCZAK, MARCIN BERNARD · 2014 to 2023
$3.8M
NEI NIH HHS P30 EY011373NEI NIH HHS R01 EY009339NEI NIH HHS R01 EY023948NEI NIH HHS R24 EY021126NEI NIH HHS R24 EY024864NEI NIH HHS R24 EY027283
6 · The paper itself

Abstract

Safe and effective molecular therapeutics for prophylactic treatment of retinal degenerative diseases are greatly needed. Disruptions in the clearance of all-

Indexed as

Alcohol OxidoreductasesAnimalsATP-Binding Cassette TransportersDiterpenesHumansMiceMice, Inbred C57BLMice, KnockoutPeptidesRetinal DegenerationVision, OcularAbca4 protein, mouseAlcohol OxidoreductasesATP-Binding Cassette TransportersDiterpenesHSD17B6 protein, mousePeptidesretinylamine

Identifiers

PMID33677964
PMCPMC8087159
OpenAlexW3134605298

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.