SynthesisEndocrinology and metabolism (Seoul, Korea)2021
Efficacy of Ethanol Ablation for Benign Thyroid Cysts and Predominantly Cystic Nodules: A Systematic Review and Meta-Analysis.
Synthesis in Endocrinology and metabolism (Seoul, Korea), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Ablative Technologies for Thyroid Nodules: A Health Technology Assessment.Ontario health technology assessment series · 2026Pooled it
- Ethanol ablation of cystic thyroid nodules: institutional experience with one year follow-up.La Radiologia medica · 2026Article
- Efficacy of thyroid cyst sclerotherapy with polidocanol.Radiology and oncology · 2026Article
- Efficacy of dual-modality ablation for symptomatic cystic thyroid nodules.Gland surgery · 2026Article
- Ablation of cystic thyroid nodules with or without the injection of ethanol prior to aspiration: a one-year follow-up study.Updates in surgery · 2026Article
- Post-procedural Thyroid Cyst Infection Following Aspiration and Polidocanol Sclerotherapy: A Case Report.Cureus · 2026Article
- Clinical outcomes of medical therapy, EUS-guided ethanol ablation, and surgical resection in insulinoma: a clinical epidemiology study.Frontiers in endocrinology · 2026Article
- Comparison of microwave ablation versus lauromacrogol injection ablation for 50-75% cystic thyroid nodules: a two-center retrospective study.Frontiers in endocrinology · 2026Article
- Status of thyroid surgery-related medical disputes in China.Gland surgery · 2025Article
- Complications after thermal ablation for thyroid nodules across countries.Frontiers in endocrinology · 2025Article
- The Comparison of Efficacy and Safety between Radiofrequency Ablation Alone and Ethanol Ablation Followed by Radiofrequency Ablation in the Treatment of Mixed Cystic and Solid Thyroid Nodule.Journal of the Korean Society of Radiology · 2024Article
- A clinical practice review of percutaneous ethanol injection for thyroid nodules: state of the art for benign, cystic lesions.Gland surgery · 2024Review
- Current role of interventional radiology in thyroid nodules.Frontiers in endocrinology · 2024Review
- Ultrasound-guided ethanol ablation versus the Sistrunk operation as a primary treatment for thyroglossal duct cysts.Ultrasonography (Seoul, Korea) · 2024Article
- Ultrasound-Guided Ethanol Ablation for Thyroglossal Duct Cyst: A Review of Technical Issues and Potential as a New Standard Treatment.Journal of clinical medicine · 2023Review
- Image-Guided Percutaneous Ablation for Primary and Metastatic Tumors.Diagnostics (Basel, Switzerland) · 2022Review
- Clinical and functional results of radiofrequency ablation and microwave ablation in patients with benign thyroid nodules.Saudi medical journal · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUltrasound-guided minimally invasive procedures are widely used to treat thyroid diseases. The objective of this study was to assess the efficacy and safety of ethanol ablation (EA) in comparison with other non-surgical options in the treatment of benign thyroid cystic nodules.
methodsWe conducted a systematic search of studies on EA for thyroid cystic nodules, mainly in the Ovid-MEDLINE and Embase, Web of Science, and Cochrane databases. The standardized mean difference (SMD) of the volume reduction ratio (VRR) after EA versus other non-surgical treatments comprised the primary outcome, whereas the odds ratio (OR) of therapeutic success rates between the two groups comprised the secondary outcome.
resultsThe meta-analysis included 19 studies (four randomized controlled trials and 15 non-randomized studies) with 1,514 participants. The cumulative VRR of EA was 83.908% (95% confidence interval [CI], 79.358% to 88.457%). EA had a significantly higher pooled VRR (SMD, 0.381; 95% CI, 0.028 to 0.734; P=0.030), but not a significantly higher pooled therapeutic success rate (OR, 0.867; 95% CI, 0.132 to 5.689; P=0.880), than other forms of non-surgical management including radiofrequency ablation (RFA), polidocanol sclerotherapy, and simple aspiration with or without saline flush. However, the VRR and therapeutic success rate were not significantly different between EA and RFA. Major complications were recorded only in six patients (0.53%) with self-limiting dysphonia.
conclusionThe role of EA as the first-line treatment for benign thyroid cysts and predominantly cystic nodules is supported by its high effectiveness and good safety profile compared to other currently available non-surgical options.
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