Evidence map›Paper›PMID 33677787›Full record

ArticleHepatology international2021

Sofosbuvir/velpatasvir for patients with chronic hepatitis C virus infection and compensated liver disease: real-world data in Taiwan.

Chen-Hua Liu, Po-Yueh Chen, Jyh-Jou Chen, Ching-Chu Lo, Wei-Wen Su, Kuo-Chih Tseng, Chun-Jen Liu, Chia-Sheng Huang, Ke-Jhang Huang, Sheng-Shun Yang and 19 more

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Article in Hepatology international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

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  5. [Recent Advances in the Treatment of Chronic Hepatitis C].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 14 institutions in 1 country.

Chen-Hua LiuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Po-Yueh ChenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan.
Jyh-Jou ChenDivision of Gastroenterology and Hepatology, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
Ching-Chu LoDepartment of Internal Medicine, St. Martin De Porres Hospital, Daya, Chiayi, Taiwan.
Wei-Wen SuDivision of Gastroenterology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Kuo-Chih TsengDepartment of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.
Chun-Jen LiuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chia-Sheng HuangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Yang Ming Hospital, Chiayi, Taiwan.
Ke-Jhang HuangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, China Medical University Beigang Hospital, Yunlin, Taiwan.
Sheng-Shun YangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Cheng-Yuan PengCenter for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
Ming-Chang TsaiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Wei-Yu KaoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
Chi-Yang ChangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Fu Jen Catholic University Hospital, Taipei, Taiwan.
Yu-Lueng ShihDivision of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Yu-Jen FangDepartment of Internal Medicine, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan.
Chi-Yi ChenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan.
Pei-Lun LeeDivision of Gastroenterology and Hepatology, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
Jow-Jyh HuangDepartment of Internal Medicine, St. Martin De Porres Hospital, Daya, Chiayi, Taiwan.
Pei-Yuan SuDivision of Gastroenterology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Chi-Wei TsengDepartment of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.
Chien-Ching HungDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chung-Hsin ChangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Yi-Jie HuangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Hsueh-Chou LaiCenter for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
Chun-Chao ChangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
Fu-Jen LeeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Fu Jen Catholic University Hospital, Taipei, Taiwan.
Tsai-Yuan HsiehDivision of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Jia-Horng KaoDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. kaojh@ntu.edu.tw.ORCID http://orcid.org/0000-0002-2442-7952
Fu Jen Catholic University · TWChina Medical University · TWNational Taiwan University Hospital · TWChanghua Christian Hospital · TWChia-Yi Christian Hospital · TWChi Mei Medical Center · TWNational Taiwan University · TWSt. Martin de Porres Hospital · TWTri-Service General Hospital · TWTzu Chi University · TWChung Shan Medical University Hospital · TWNational Chung Hsing University · TWTaichung Veterans General Hospital · TWTaipei Medical University Hospital · TW

Funding

Ministry of Science and Technology, Taiwan 106-2314-B-002-138-MY3Ministry of Science and Technology, Taiwan 107-2314-B-002-038-MY2
6 · The paper itself

Abstract

backgroundData regarding the real-world effectiveness and safety of sofosbuvir/velpatasvir (SOF/VEL) for East Asian patients with chronic hepatitis C virus (HCV) infection and compensated liver disease are limited. We evaluated the performance of SOF/VEL for 12 weeks for HCV-infected patients with compensated liver disease in a large real-world cohort in Taiwan.

methodsBetween July 2019 and March 2020, 1880 HCV-infected patients with compensated liver disease who received SOF/VEL 400/100 mg once daily for 12 weeks were included at 15 academic centers in Taiwan. The sustained virologic response at off-treatment week 12 (SVR

resultsThe SVR

conclusionsSOF/VEL for 12 weeks is efficacious and well-tolerated by chronic HCV-infected patients with compensated liver disease in Taiwan.

Indexed as

Hepatitis C, ChronicAntiviral AgentsBenzimidazolesBenzopyransCarbamatesGenotypeHepacivirusHeterocyclic Compounds, 4 or More RingsHumansSofosbuvirSustained Virologic ResponseTaiwanAntiviral AgentsBenzimidazolesBenzopyransCarbamatesHeterocyclic Compounds, 4 or More RingsSofosbuvirvelpatasvirAdverse eventDirect acting antiviralEast AsianEffectivenessHepatitis C virusPangenotypicSafetySofosbuvirSustained virologic responseVelpatasvir

Identifiers

PMID33677787
OpenAlexW3126774076

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.