Evidence map›Paper›PMID 33677781›Full record

Trial reportBreast cancer research and treatment2021

Examining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention.

ThaiHien Nguyen, Melinda L Irwin, Andrew T Dewan, Brenda Cartmel, Maura Harrigan, Leah M Ferrucci, Tara Sanft, Fangyong Li, Lingeng Lu, Yasmmyn D Salinas

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Breast cancer research and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02110641 nacompletednot on this map

Lifestyle, Exercise and Nutrition (LEAN) Study 2

TypeinterventionalSponsorYale UniversityRan2013 to 2016Enrolled51ConditionsBreast Cancer, Weight LossArmsWeight Loss Counseling
NCT02863887 nacompletednot on this map

The Lifestyle Changes Through Exercise and Nutrition (LEAN) Project

TypeinterventionalSponsorPennington Biomedical Research CenterRan2016 to 2017Enrolled97ConditionsObesity, DiabetesArmsWeight loss intervention
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

ThaiHien NguyenYale School of Public Health, MPH, 55 Church Street, Suite 801, New Haven, CT, 06510, USA. thaihien.nguyen@yale.edu.ORCID http://orcid.org/0000-0002-4293-3488
Melinda L IrwinYale School of Public Health, MPH, 55 Church Street, Suite 801, New Haven, CT, 06510, USA.
Andrew T DewanYale School of Public Health, MPH, 55 Church Street, Suite 801, New Haven, CT, 06510, USA.
Brenda CartmelYale School of Public Health, MPH, 55 Church Street, Suite 801, New Haven, CT, 06510, USA.
Maura HarriganYale School of Public Health, MPH, 55 Church Street, Suite 801, New Haven, CT, 06510, USA.
Leah M FerrucciYale School of Public Health, MPH, 55 Church Street, Suite 801, New Haven, CT, 06510, USA.
Tara SanftYale Cancer Center, Yale University School of Medicine, New Haven, CT, USA.
Fangyong LiYale School of Public Health, MPH, 55 Church Street, Suite 801, New Haven, CT, 06510, USA.
Lingeng LuYale School of Public Health, MPH, 55 Church Street, Suite 801, New Haven, CT, 06510, USA.
Yasmmyn D SalinasYale School of Public Health, MPH, 55 Church Street, Suite 801, New Haven, CT, 06510, USA.
Yale University · USYale Cancer Center · US

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Opening the Black Box of Machine Learning ModelsR35GM128638 · NIGMS · UNIVERSITY OF WASHINGTON · PI LEE, SU-IN · 2018 to 2022
$1.9M
NCATS NIH HHS UL1 TR000142NCI NIH HHS P30 CA016359NIGMS NIH HHS R35 GM128638
6 · The paper itself

Abstract

purposeOur study examined whether common variants of obesity-associated genes FTO, MC4R, BDNF, and CREB1 moderated the effects of a lifestyle intervention on weight change among breast cancer survivors.

methods151 breast cancer survivors with a body mass index ≥ 25 kg/m

resultsWomen in the intervention group achieved significantly greater weight loss than the usual care group (5.9% vs 0.4%, p < 0.001), regardless of genotype. Changes in weight and percent body fat did not differ significantly between carriers of the FTO rs9939609, MC4R rs6567160, BDNF rs11030104, and CREB1 rs17203016 risk alleles compared to non-carriers (p-interaction > 0.0125 for each single-nucleotide polymorphisms).

conclusionsWomen who are genetically predisposed to obesity and recently diagnosed with breast cancer may achieve significant and clinically meaningful weight loss through healthy eating and exercise. CLINICAL

trial registrationNCT02863887 (Date of Registration: August 11, 2016); NCT02110641 (Date of Registration: April 10, 2014).

Indexed as

Breast NeoplasmsCancer SurvivorsAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody Mass IndexFemaleGenotypeHumansObesityPolymorphism, Single NucleotideWeight LossAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanBreast CancerExerciseGeneticsNutritionObesityWeight loss

Identifiers

PMID33677781
OpenAlexW3135075854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.