Evidence map›Paper›PMID 33677746›Full record

ArticleJournal of assisted reproduction and genetics2021

Reproductive outcomes after preimplantation genetic testing in mosaic Turner syndrome: a retrospective cohort study of 100 cycles.

Jingnan Liao, Keli Luo, Dehua Cheng, Pingyuan Xie, Yueqiu Tan, Liang Hu, Guangxiu Lu, Fei Gong, Ge Lin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jingnan LiaoInstitute of Reproductive and Stem Cell Engineering, Central South University, Changsha, 410008, China.ORCID http://orcid.org/0000-0002-0392-6517
Keli LuoClinical Research Center For Reproduction and Genetics In Hunan Province, Changsha, 410008, China.
Dehua ChengInstitute of Reproductive and Stem Cell Engineering, Central South University, Changsha, 410008, China.
Pingyuan XieInstitute of Reproductive and Stem Cell Engineering, Central South University, Changsha, 410008, China.
Yueqiu TanInstitute of Reproductive and Stem Cell Engineering, Central South University, Changsha, 410008, China.
Liang HuInstitute of Reproductive and Stem Cell Engineering, Central South University, Changsha, 410008, China.
Guangxiu LuInstitute of Reproductive and Stem Cell Engineering, Central South University, Changsha, 410008, China.
Fei GongInstitute of Reproductive and Stem Cell Engineering, Central South University, Changsha, 410008, China.
Ge LinInstitute of Reproductive and Stem Cell Engineering, Central South University, Changsha, 410008, China. linggf@hotmail.com.
Central South University · CNHunan Provincial Center for Disease Control and Prevention · CN

Funding

Hunan Provincial Grant for Innovative Province Construction 2019SK4012National Key Research and Development Program of China Project 2016YFC1000200National Natural Science Foundation of China NO.81974230
6 · The paper itself

Abstract

purposeThe purpose of this study is to explore the reproductive outcomes of women with Turner syndrome (TS) in preimplantation genetic testing (PGT) cycles.

methodsA retrospective study of 100 controlled ovarian stimulating cycles, 68 TS (sixty-four mosaic Turner syndrome (MTS) and four pure Turner syndrome (PTS)) women underwent PGT was conducted from 2013 to 2018.

resultsEmbryo X chromosome abnormal rates of TS women were significantly higher than women with normal karyotype (7.04 vs 1.61%, P<0.01). Cumulative live birth rates (CLBR) after PGT-NGS treatment were lower in TS than control (31.15 vs 45.59%, P<0.05). Clinical pregnancy rates per transfer (CPR), miscarriage rates (MR) and live birth rates per transfer (LBR) remained comparable between TS and control group. Reproductive outcomes (X chromosome abnormal rates, CPR, MR, LBR and CLBR) among low (<10%), medium (10-50%) and high (>50%) level 45,X mosaicism groups were not statistically different.

conclusionsTo avoid high risk of embryo X chromosome abnormalities, prenatal or preimplantation genetic testing should be recommended to mosaic or pure TS patients.

Indexed as

MosaicismPreimplantation DiagnosisAbortion, SpontaneousAdultAneuploidyBirth RateBlastocystEmbryo TransferFemaleFertilization in VitroGenetic TestingHumansLive BirthPregnancyPregnancy RateTurner SyndromeAneuploidy,Live birth rate,Mosaicism,Preimplantation genetic screening,Turner syndrome (TS)

Identifiers

PMID33677746
PMCPMC8190244
OpenAlexW3134094639

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.