ArticleAMB Express2021
Effects of altitude on human oral microbes.
Article in AMB Express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Use ofFrontiers in immunology · 2023Trial
- Trial
- Salivary microbiome and metabolome profiles associated with dental caries in Tibetan children from high-altitude regions.Odontology · 2026Article
- Short-Term High-Altitude Exposure Alters Pharyngeal and Gut Microbiome.Environment & health (Washington, D.C.) · 2026Article
- Probiotic potential ofVeterinary world · 2026Article
- [Oral homeostasis imbalance under hypoxia].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026Review
- Vaginal microecological characterization of women of childbearing age at different altitudes: a multi-omics exploration.BMC women's health · 2025Article
- Platelet methyltransferase-like protein 4-mediated mitochondrial DNA metabolic disorder exacerbates oral mucosal immunopathology in hypoxia.International journal of oral science · 2025Article
- A human skin microbiome reference catalog and the skin microbial landscape of plateau adults.iMetaOmics · 2025Article
- A cross-sectional investigation on oral health and hygiene among children aged 7-10 years in extremely high altitude areas of China.Scientific reports · 2025Article
- Botulism in the Highlands: Understanding the High-Altitude Effect.Journal of epidemiology and global health · 2025Review
- Saliva assay: a call for methodological standardization.Journal of periodontal & implant science · 2025Review
- Article
- The Effect of Acute High-Altitude Exposure on Oral Pathogenic Bacteria and Salivary Oxi-Inflammatory Markers.Journal of clinical medicine · 2024Article
- Altitude shapes gut microbiome composition accounting for diet, thyroid hormone levels, and host genetics in a subterranean blind mole rat.Frontiers in microbiology · 2024Article
- Comparative analysis of oral saliva microbiomes and metabolites in Han population at different altitudes.Frontiers in microbiology · 2024Article
- Impact of high altitude on composition and functional profiling of oral microbiome in Indian male population.Scientific reports · 2023Article
- Article
- Highland adaptation of birds on the Qinghai-Tibet Plateau via gut microbiota.Applied microbiology and biotechnology · 2022Article
- Chromosome-level genome assemblies of four wild peach species provide insights into genome evolution and genetic basis of stress resistance.BMC biology · 2022Article
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Authors and funding
10 authors.
Funding
Abstract
Human oral microbes play a vital role maintaining host metabolic homeostasis. The Qinghai-Tibet Plateau is mainly characterized by a high altitude, dry, cold, and hypoxic environment. The oral microbiota is subject to selective pressure from the plateau environment, which affects oral health. Only a few studies have focused on the characteristics of oral microbiota in high-altitude humans. We collected saliva samples from 167 Tibetans at four altitudes (2800 to 4500 m) in Tibet to explore the relationship between the high altitude environment and oral microbiota. We conducted a two (high- and ultra-high-altitude) group analysis based on altitude, and adopted the 16S rRNA strategy for high-throughput sequencing. The results show that the alpha diversity of the oral microbiota decreased with altitude, whereas beta diversity increased with altitude. A LEfSe analysis revealed that the oral microbial biomarker of the high-altitude group (< 3650 m) was Streptococcus, and the biomarker of the ultra-high-altitude group (> 4000 m) was Prevotella. The relative abundance of Prevotella increased with altitude, whereas the relative abundance of Streptococcus decreased with altitude. A network analysis showed that the microbial network structure was more compact and complex, and the interaction between the bacterial genera was more intense in the high altitude group. Gene function prediction results showed that the amino acid and vitamin metabolic pathways were upregulated in the ultra-high-altitude group. These result show that altitude is an important factor affecting the diversity and community structure of the human oral microbiota.
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