Evidence map›Paper›PMID 33677717›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

Effect of perioperative pain neuroscience education in patients with post-mastectomy persistent pain: a retrospective, propensity score-matched study.

Masahiro Manfuku, Tomohiko Nishigami, Akira Mibu, Hirofumi Yamashita, Ryota Imai, Katsuyoshi Tanaka, Kazufumi Kitagaki, Kanamori Hiroe, Kazuhiro Sumiyoshi

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06052085 (Investigation of the Efficiency of Pain Neuroscience Education in Patients With Chronic Pain After Breast Cancer Surgery), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06052085 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Investigation of the Efficiency of Pain Neuroscience Education in Patients With Chronic Pain After Breast Cancer Surgery

TypeinterventionalSponsorHacettepe UniversityRan2023 to 2025Enrolled50ConditionsBreast CancerArmsPain Neuroscience Education, Biomedical Pain Education, Standard Physiotherapy Program
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Masahiro ManfukuDepartment of Rehabilitation, Breast Care Sensyu Clinic, Osaka, Japan.ORCID https://orcid.org/0000-0003-2537-7106
Tomohiko NishigamiDepartment of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima, Hiroshima, Japan. tomon@pu-hiroshima.ac.jp.ORCID http://orcid.org/0000-0002-6969-8916
Akira MibuDepartment of Physical Therapy, Konan Women's University, Kobe, Hyogo, Japan.
Hirofumi YamashitaDepartment of Rehabilitation, Nozomi Orthopaedic Clinic Saijo, Hiroshima, Japan.
Ryota ImaiDepartment of Rehabilitation, Osaka Kawasaki Rehabilitation University, Osaka, Japan.
Katsuyoshi TanakaDepartment of Rehabilitation, Tanabe Orthopaedics, Osaka, Japan.
Kazufumi KitagakiDepartment of Cardiovascular Rehabilitation, National Cerebral and Cardiovascular Center, Osaka, Japan.
Kanamori HiroeDepartment of Breast Surgery, Breast Care Sensyu Clinic, Osaka, Japan.
Kazuhiro SumiyoshiDepartment of Breast Surgery, Breast Care Sensyu Clinic, Osaka, Japan.
Tokushima Breast Care Clinic · JPKonan Women's University · JPNational Cerebral and Cardiovascular Center · JPOsaka Kawasaki Rehabilitation University · JPPrefectural University of Hiroshima · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCentral sensitization (CS)-related symptoms and pain catastrophizing contribute to persistent post-mastectomy pain (PPMP). Pain neuroscience education (PNE) is effective in reducing CS-related symptoms and pain catastrophizing in patients with chronic pain. However, to date, no intervention study of PNE has been conducted to patients with PPMP. This study was aimed to examine whether PNE is more effective than biomedical education (BME) for PPMP.

methodsIn this retrospective case-control study, 118 patients were included. We intervened different patients at different times as follows: (1) a BME group (n = 58) of patients who received BME combined with physiotherapy and (2) a PNE group (n = 60) of patients who received PNE combined with physiotherapy. One year after surgery, we assessed pain intensity and interference (brief pain inventory [BPI]), CS-related symptoms (central sensitization inventory [CSI]), and pain catastrophizing (pain catastrophizing scale [PCS]). Propensity score matching was used to reduce or minimize selection bias and confounding biases and to make the number of cases in both groups match 1:1.

resultsPropensity score matching generated the BME group (n = 51) and the PNE group (n = 51). The BPI score, CSI score, and PCS score were statistically significantly lower in the PNE group than in the BME group (all, p < 0.05). The effect sizes for the BPI intensity (r = 0.31) were moderate.

conclusionsPNE resulted in a better outcome of pain management with less functional disability and CS-related symptoms compared to BME after breast surgery.

Indexed as

Breast NeoplasmsChronic PainMastectomyFemaleHumansPatient Education as TopicPropensity ScoreRetrospective StudiesBreast cancerCancer rehabilitationPain neuroscience educationPersistent post-mastectomy painPropensity score matching

Identifiers

PMID33677717
OpenAlexW3134381202

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.