ReviewJournal of neurology2022
Is postural orthostatic tachycardia syndrome (POTS) a central nervous system disorder?
Review in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- POTS: A neuroimmune disorder with cardiovascular manifestations?Heart rhythm O2 · 2026Article
- An alternative "Port"? Rationale and development process for POts Reprocessing Therapy (PORT), a brain-body therapy for postural tachycardic syndrome (POTS).Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Dysphagia Symptoms in Patients with Postural Orthostatic Tachycardia Syndrome (POTS): A Qualitative Study.Neurology international · 2026Article
- The body and the brain keep the score: a data-driven conceptual model linking trauma and postural tachycardia syndrome.Frontiers in psychology · 2026Review
- Postural Orthostatic Tachycardia Syndrome, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID as Neuroimmune Disorders.ImmunoTargets and therapy · 2026Review
- Regulation of Cardiac Function by the Autonomic Nervous System.Physiology (Bethesda, Md.) · 2025Review
- Outcomes of Pediatric Patients with Excessive Postural Tachycardia After Attending an Intensive Interdisciplinary Pain Program: A Pilot Study.Children (Basel, Switzerland) · 2025Article
- Neuroinflammation at the Dorsolateral Inferior Medulla: A Possible Central Nervous System Localization for POTS and Long COVID.Biomedicines · 2025Article
- Potential Mechanisms of COVID-19 Related Nervous System Damage and Effects on Female Fertility.Current medicinal chemistry · 2025Review
- Neurobiological and neuropsychological disturbance in EDS.Frontiers in neurology · 2025Review
- Differential diagnosis of orthostatic dizziness with persistent postural-perceptual dizziness and its underlying mechanisms.Frontiers in neurology · 2025Review
- Pathophysiological mechanisms of Postural Orthostatic Tachycardia Syndrome analyzed by means of hemodynamics.PloS one · 2025Article
- Progressive episodes of recurrent syncope due to postural orthostatic tachycardia syndrome truncated by paroxetine: a case report.Frontiers in psychiatry · 2025Article
- Exercise in Postural Orthostatic Tachycardia Syndrome: Focus on Individualized Exercise Approach.Journal of clinical medicine · 2024Review
- The relationship between cardiovagal baroreflex and cerebral autoregulation in postural orthostatic tachycardia disorder using advanced cross-correlation function.Scientific reports · 2024Article
- Article
- Postural Orthostatic Tachycardia Syndrome Associated with COVID-19: A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- Plasma metabolomic profile in orthostatic intolerance children with high levels of plasma homocysteine.Italian journal of pediatrics · 2024Article
- Cardiovascular, autonomic symptoms and quality of life in children with hypermobile Ehlers-Danlos syndrome.SAGE open medicine · 2024Article
- Cognitive functioning in postural orthostatic tachycardia syndrome among different body positions: a prospective pilot study (POTSKog study).Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postural orthostatic tachycardia syndrome (POTS), a disorder of the autonomic nervous system characterized by a rise in heart rate of at least 30 bpm from supine to standing position, has been traditionally viewed as a dysfunction of the peripheral nervous system. However, recent studies and evidence from overlapping conditions suggest that in addition to being considered a disorder of the peripheral nervous system, POTS should be viewed also as a central nervous system (CNS) disorder given (1) significant CNS symptom burden in patients with POTS; (2) structural and functional differences found on neuroimaging in patients with POTS and other forms of orthostatic intolerance; (3) evidence of cerebral hypoperfusion and possible alteration in cerebrospinal fluid volume, and (4) positive response to medications targeting the CNS and non-pharmacologic CNS therapies. This review outlines existing evidence of POTS as a CNS disorder and proposes a hypothetical model combining key mechanisms in the pathophysiology of POTS. Redefining POTS as a CNS disorder can lead to new possibilities in pharmacotherapy and non-pharmacologic therapeutic interventions in patents affected by this disabling syndrome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.