Evidence map›Paper›PMID 33677645›Full record

ArticleEuropean radiology2021

Radiomics model of dual-time 2-[

Zhaobang Liu, Ming Li, Changjing Zuo, Zehong Yang, Xiaokai Yang, Shengnan Ren, Ye Peng, Gaofeng Sun, Jun Shen, Chao Cheng and 1 more

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Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  15. Distinction of Lymphoma from Sarcoidosis onJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
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  17. Insights into imaging · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhaobang LiuSchool of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.
Ming LiDepartment of Medical Imaging, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, 88 Keling Road, Suzhou, 215163, China.
Changjing ZuoDepartment of Nuclear Medicine, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China.
Zehong YangDepartment of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Xiaokai YangWenzhou People's Hospital, Wenzhou Medical University, Wenzhou, 325041, China.
Shengnan RenDepartment of Nuclear Medicine, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China.
Ye PengDepartment of Nuclear Medicine, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China.
Gaofeng SunDepartment of Nuclear Medicine, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China.
Jun ShenDepartment of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Chao ChengDepartment of Nuclear Medicine, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China. 13501925757@163.com.
Xiaodong YangDepartment of Medical Imaging, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, 88 Keling Road, Suzhou, 215163, China. xiaodong.yang@sibet.ac.cn.ORCID http://orcid.org/0000-0002-5828-307X

Funding

Medical artificial intelligence project of Sun Yat-Sen Memorial Hospital YXRGZN201905National Key Research and Development Program of China 2016YFC0103502National Natural Science Foundation of China 61701492Wenzhou Science and Technology Foundation ZS2017020
6 · The paper itself

Abstract

objectivesPancreatic ductal adenocarcinoma (PDAC) and autoimmune pancreatitis (AIP) are diseases with a highly analogous visual presentation that are difficult to distinguish by imaging. The purpose of this research was to create a radiomics-based prediction model using dual-time PET/CT imaging for the noninvasive classification of PDAC and AIP lesions.

methodsThis retrospective study was performed on 112 patients (48 patients with AIP and 64 patients with PDAC). All cases were confirmed by imaging and clinical follow-up, and/or pathology. A total of 502 radiomics features were extracted from the dual-time PET/CT images to develop a radiomics decision model. An additional 12 maximum intensity projection (MIP) features were also calculated to further improve the radiomics model. The optimal radiomics feature set was selected by support vector machine recursive feature elimination (SVM-RFE), and the final classifier was built using a linear SVM. The performance of the proposed dual-time model was evaluated using nested cross-validation for accuracy, sensitivity, specificity, and area under the curve (AUC).

resultsThe final prediction model was developed from a combination of the SVM-RFE and linear SVM with the required quantitative features. The multimodal and multidimensional features performed well for classification (average AUC: 0.9668, accuracy: 89.91%, sensitivity: 85.31%, specificity: 96.04%).

conclusionsThe radiomics model based on 2-[ KEY POINTS: • The clinical symptoms and imaging visual presentations of PDAC and AIP are highly similar, and accurate differentiation of PDAC and AIP lesions is difficult. • Radiomics features provided a potential noninvasive method for differentiation of AIP from PDAC. • The diagnostic performance of the proposed radiomics model indicates its potential to assist doctors in making treatment decisions.

Indexed as

Autoimmune PancreatitisCarcinoma, Pancreatic DuctalPancreatic NeoplasmsDiagnosis, DifferentialFluorodeoxyglucose F18HumansPositron Emission Tomography Computed TomographyRetrospective StudiesFluorodeoxyglucose F18Autoimmune pancreatitis (AIP)Carcinoma, pancreatic ductalPancreatic neoplasmsPositron emission tomography/computerized tomography (PET/CT)Radiomics

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.