ArticleMolecular biology and evolution2021
The Genomic Architecture of Adaptation to Larval Malnutrition Points to a Trade-off with Adult Starvation Resistance in Drosophila.
Article in Molecular biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Beyond fixation: persistent genetic variation under intense selection.Molecular biology and evolution · 2026Article
- Beyond Fixation: Persistent Genetic Variation Under Intense Selection.bioRxiv : the preprint server for biology · 2026Article
- Rapid Genomic Adaptation of Drosophila Melanogaster to Wolbachia Elimination.Microbial ecology · 2026Article
- Strength of selection potentiates distinct adaptive responses in an evolution experiment with outcrossing yeast.G3 (Bethesda, Md.) · 2026Article
- Estimating the additive genetic variance for relative fitness from changes in allele frequency.Genetics · 2026Article
- Variation in the resource environment affects patterns of seasonal adaptation at phenotypic and genomic levels inEvolution letters · 2025Article
- Pervasive sex-dependent effects in the genetic architecture of starvation resistance inScience advances · 2025Article
- Continent-wide differentiation of fitness traits and patterns of climate adaptation among European populations ofEvolution letters · 2025Article
- Extreme genetic signatures of local adaptation in a notorious rice pest,National science review · 2025Article
- Shared genetic architecture links energy metabolism, behavior and starvation resistance along a power-endurance axis.Evolution letters · 2025Article
- Nutritional stress in larvae induces adaptive responses that transcend generations in males of a model insect.The Journal of experimental biology · 2025Article
- Animal models for understanding the mechanisms of malnutrition: a literature review.Frontiers in nutrition · 2025Review
- Cis-regulatory polymorphism at fiz ecdysone oxidase contributes to polygenic evolutionary response to malnutrition in Drosophila.PLoS genetics · 2024Article
- Evolutionary adaptation to juvenile malnutrition impacts adult metabolism and impairs adult fitness ineLife · 2023Article
- Experimental evolution of metabolism under nutrient restriction: enhanced amino acid catabolism and a key role of branched-chain amino acids.Evolution letters · 2023Article
- Adaptation in Outbred Sexual Yeast is Repeatable, Polygenic and Favors Rare Haplotypes.Molecular biology and evolution · 2022Article
- Genome-wide selection signatures reveal widespread synergistic effects of two different stressors inProceedings. Biological sciences · 2022Article
- Nutritional phenotype underlines the performance trade-offs ofCurrent research in insect science · 2022Article
- Sexual Antagonism, Temporally Fluctuating Selection, and Variable Dominance Affect a Regulatory Polymorphism in Drosophila melanogaster.Molecular biology and evolution · 2021Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Periods of nutrient shortage impose strong selection on animal populations. Experimental studies of genetic adaptation to nutrient shortage largely focus on resistance to acute starvation at adult stage; it is not clear how conclusions drawn from these studies extrapolate to other forms of nutritional stress. We studied the genomic signature of adaptation to chronic juvenile malnutrition in six populations of Drosophila melanogaster evolved for 150 generations on an extremely nutrient-poor larval diet. Comparison with control populations evolved on standard food revealed repeatable genomic differentiation between the two set of population, involving >3,000 candidate SNPs forming >100 independently evolving clusters. The candidate genomic regions were enriched in genes implicated in hormone, carbohydrate, and lipid metabolism, including some with known effects on fitness-related life-history traits. Rather than being close to fixation, a substantial fraction of candidate SNPs segregated at intermediate allele frequencies in all malnutrition-adapted populations. This, together with patterns of among-population variation in allele frequencies and estimates of Tajima's D, suggests that the poor diet results in balancing selection on some genomic regions. Our candidate genes for tolerance to larval malnutrition showed a high overlap with genes previously implicated in acute starvation resistance. However, adaptation to larval malnutrition in our study was associated with reduced tolerance to acute adult starvation. Thus, rather than reflecting synergy, the shared genomic architecture appears to mediate an evolutionary trade-off between tolerances to these two forms of nutritional stress.
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