ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
Effect of Dietary Protein Intake on Bone Mineral Density and Fracture Incidence in Older Adults in the Health, Aging, and Body Composition Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Management of Osteoporosis in Parkinson's Disease: A Systematic Review of Clinical Practice Guidelines.Movement disorders clinical practice · 2025Pooled it
- Interaction of Dietary Patterns and Physical Activity with Low Back Pain in Pre- to Post-Menopause: A Cross-Sectional Study.Journal of health, population, and nutrition · 2026Article
- Association between dietary protein intake and bone mineral density in adolescents: a cross-sectional study.Archives of osteoporosis · 2025Article
- Association between dietary protein intake and bone mineral density based on NHANES 2011-2018.Scientific reports · 2025Article
- The Effect of Protein Intake on Bone Disease, Kidney Disease, and Sarcopenia: A Systematic Review.Current developments in nutrition · 2025Review
- Role of protein intake in maintaining muscle mass composition among elderly females suffering from sarcopenia.Frontiers in nutrition · 2025Article
- Reversal of Bone Mineral Density Loss Through Lifestyle Changes: A Case Report.American journal of lifestyle medicine · 2025Article
- Study on the correlation between dietary patterns and bone health among rural elderly people in Qingdao.Frontiers in nutrition · 2025Article
- Dairy and Exercise for Bone Health: Evidence from Randomized Controlled Trials and Recommendations for Future Research.Current osteoporosis reports · 2024Review
- Identification of nutrition factors in the metabolic syndrome and its progression over time in older adults: analysis of the TUDA cohort.Diabetology & metabolic syndrome · 2024Article
- Three-Year Mortality of Older Hospitalized Patients with Osteosarcopenia: Data from the OsteoSys Study.Nutrients · 2024Article
- The multi-faceted nature of age-associated osteoporosis.Bone reports · 2024Review
- Discussion on protein recommendations for supporting muscle and bone health in older adults: a mini review.Frontiers in nutrition · 2024Review
- Protein intake and bone mineral density: Cross-sectional relationship and longitudinal effects in older adults.Journal of cachexia, sarcopenia and muscle · 2023Article
- Associations between Macronutrients Intake and Bone Mineral Density: A Longitudinal Analysis of the Health Workers Cohort Study Participants.The journal of nutrition, health & aging · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundDietary recommendations may underestimate the protein older adults need for optimal bone health. This study sought to determine associations of protein intake with bone mineral density (BMD) and fracture among community-dwelling White and Black older adults.
methodProtein as a percentage of total energy intake (TEI) was assessed with a Food Frequency Questionnaire in 2160 older adults (73.5 ± 2.8 years; 51.5% women; 35.8% Black) in the Health, Aging, and Body Composition prospective cohort. Hip, femoral neck, and whole body BMD was assessed by dual-energy x-ray absorptiometry at baseline and 4 years, and lumbar trabecular, cortical, and integral BMD was assessed by computed tomography at baseline and 5 years. Fragility fractures over 5 years were adjudicated from self-report data collected every 6 months. Associations with tertiles of protein intake were assessed using analysis of covariance for BMD and multivariate Cox regression for fracture, adjusting for confounders.
resultsParticipants in the upper protein tertile (≥15% TEI) had 1.8%-6.0% higher mean hip and lumbar spine BMD compared to the lower protein tertile (<13% TEI; p < .05). Protein intake did not affect change in BMD at any site over the follow-up period. Participants in the upper protein tertile had a reduced risk of clinical vertebral fracture over 5 years of follow-up (hazard ratio: 0.36 [95% confidence interval: 0.14, 0.97] vs lower protein tertile, p = .04).
conclusionsOlder adults with higher protein intake (≥15% TEI) had higher BMD at the hip, whole body, and lumbar spine, and a lower risk of vertebral fracture.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.