ArticleCerebral cortex (New York, N.Y. : 1991)2021
Diminished Cortical Excitation and Elevated Inhibition During Perceptual Impairments in a Mouse Model of Autism.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Divergent representation and processing of task cues in sensory and prefrontal cortices of preterm-born mice.Nature communications · 2026Article
- Dim light at night disrupts the sleep-wake cycle and exacerbates abnormal EEG activity in Cntnap2 knockout mice: implications for autism spectrum disorders.Molecular autism · 2025Article
- Lateral inhibition in V1 controls neural and perceptual contrast sensitivity.Nature neuroscience · 2025Article
- Increased alpha power in autistic adults: Relation to sensory behaviors and cortical volume.Autism research : official journal of the International Society for Autism Research · 2025Article
- Degraded tactile coding in the Cntnap2 mouse model of autism.Cell reports · 2024Article
- Reduced excitatory activity in the developing mPFC mediates a PVTranslational psychiatry · 2024Article
- Interneuron-Targeted Disruption ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Robust odor identification in novel olfactory environments in mice.Nature communications · 2023Article
- Circuit-level theories for sensory dysfunction in autism: convergence across mouse models.Frontiers in neurology · 2023Review
- Optimizing intact skull intrinsic signal imaging for subsequent targeted electrophysiology across mouse visual cortex.Scientific reports · 2022Article
- Cell-type specific transcriptomic signatures of neocortical circuit organization and their relevance to autism.Frontiers in neural circuits · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Sensory impairments are a core feature of autism spectrum disorder (ASD). These impairments affect visual perception and have been hypothesized to arise from imbalances in cortical excitatory and inhibitory activity. There is conflicting evidence for this hypothesis from several recent studies of transgenic mouse models of ASD; crucially, none have measured activity from identified excitatory and inhibitory neurons during simultaneous impairments of sensory perception. Here, we directly recorded putative excitatory and inhibitory population spiking in primary visual cortex (V1) while simultaneously measuring visual perceptual behavior in CNTNAP2-/- knockout (KO) mice. We observed quantitative impairments in the speed, accuracy, and contrast sensitivity of visual perception in KO mice. During these perceptual impairments, stimuli evoked more firing of inhibitory neurons and less firing of excitatory neurons, with reduced neural sensitivity to contrast. In addition, pervasive 3-10 Hz oscillations in superficial cortical layers 2/3 (L2/3) of KO mice degraded predictions of behavioral performance from neural activity. Our findings show that perceptual deficits relevant to ASD may be associated with elevated cortical inhibitory activity along with diminished and aberrant excitatory population activity in L2/3, a major source of feedforward projections to higher cortical regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.