Evidence map›Paper›PMID 33677484›Full record

ArticleAlcohol and alcoholism (Oxford, Oxfordshire)2021

The Association between the Alcohol Biomarker Phosphatidylethanol (PEth) and Self-Reported Alcohol Consumption among Russian and Norwegian Medical Patients.

Benedicte Jørgenrud, Saranda Kabashi, Aleksei Nadezhdin, Evgeny Bryun, Evgenya Koshkina, Elena Tetenova, Anners Lerdal, Gudmund Norby, Alexey Kolgashkin, Alexei Petukhov and 5 more

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Alcohol and alcoholism (Oxford, Oxfordshire), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Benedicte JørgenrudDepartment of Forensic Sciences, Oslo University Hospital, P.O. Box 4950 Nydalen, N-0424 Oslo, Norway.ORCID 0000-0001-5917-8776
Saranda KabashiDepartment of Forensic Sciences, Oslo University Hospital, P.O. Box 4950 Nydalen, N-0424 Oslo, Norway.
Aleksei NadezhdinMoscow Research and Practical Centre on Addictions of Moscow, Department of Public Health, 109390, Ljublinskaya ul. 37/1, Moscow, Russia.
Evgeny BryunMoscow Research and Practical Centre on Addictions of Moscow, Department of Public Health, 109390, Ljublinskaya ul. 37/1, Moscow, Russia.
Evgenya KoshkinaMoscow Research and Practical Centre on Addictions of Moscow, Department of Public Health, 109390, Ljublinskaya ul. 37/1, Moscow, Russia.
Elena TetenovaMoscow Research and Practical Centre on Addictions of Moscow, Department of Public Health, 109390, Ljublinskaya ul. 37/1, Moscow, Russia.
Anners LerdalInstitute of Health and Society, Faculty of Medicine, University of Oslo, P.O. Box 1130 Blindern, N-0318 Oslo, Norway.
Gudmund NorbyMedical Department, Lovisenberg Diaconal Hospital, P.O. Box 04970, Nydalen N-0440 Oslo, Norway.
Alexey KolgashkinMoscow Research and Practical Centre on Addictions of Moscow, Department of Public Health, 109390, Ljublinskaya ul. 37/1, Moscow, Russia.
Alexei PetukhovMoscow Research and Practical Centre on Addictions of Moscow, Department of Public Health, 109390, Ljublinskaya ul. 37/1, Moscow, Russia.
Sergey PerekhodovDemikhov Moscow Clinical Hospital, 109263, Shkuljova ul. 4, str. 1, Moscow, Russia.
Elena DavydovaDemikhov Moscow Clinical Hospital, 109263, Shkuljova ul. 4, str. 1, Moscow, Russia.
Vigdis VindenesDepartment of Forensic Sciences, Oslo University Hospital, P.O. Box 4950 Nydalen, N-0424 Oslo, Norway.
Danil GamboaDepartment of Forensic Sciences, Oslo University Hospital, P.O. Box 4950 Nydalen, N-0424 Oslo, Norway.
Stig Tore BogstrandDepartment of Forensic Sciences, Oslo University Hospital, P.O. Box 4950 Nydalen, N-0424 Oslo, Norway.
Oslo University Hospital · NORussian Medical Academy of Continuous Professional Education · RULovisenberg Diakonale Høgskole · NOSechenov University · RUUniversity of Oslo · NO

Funding

Ministry of Health and Care Services B-1408
6 · The paper itself

Abstract

aimsValid measures to identify harmful alcohol use are important. Alcohol Use Disorders Identification Test (AUDIT) is a validated questionnaire used to self-report harmful drinking in several cultures and settings. Phosphatidylethanol 16:0/18:1 (PEth) is a direct alcohol biomarker measuring alcohol consumption levels. The aim of this study was to investigate how PEth levels correlate with AUDIT-QF and weekly grams of alcohol consumed among patients in two urban hospitals. In addition, we wanted to investigate the predictive value of PEth in identifying harmful alcohol use as defined by AUDIT-QF and weekly grams of alcohol cutoffs.

methodsA cross-sectional study comprising acute medically ill patients with measurable PEth levels (≥0.030 μM) admitted to two urban hospitals in Oslo, Norway (N = 931) and Moscow, Russia (N = 953) was conducted using PEth concentrations in whole blood, sociodemographic data and AUDIT-QF questionnaires.

resultsPEth levels from patients with measurable PEth were found to be positively correlated with AUDIT-QF scores, with PEth cutpoints of 0.128 μM (Oslo) and 0.270 μM (Moscow) providing optimal discrimination for harmful alcohol use defined by AUDIT-QF (the difference between cities probably reflecting different national drinking patterns in QF). When converting AUDIT-QF into weekly grams of alcohol consumed, the predictive value of PEth improved, with optimal PEth cutpoints of 0.327 (Oslo) and 0.396 (Moscow) μM discriminating between harmful and non-harmful alcohol use as defined in grams (≥350 grams/week).

conclusionsBy using PEth levels and converting AUDIT-QF into weekly grams of alcohol it was possible to get an improved rapid and sensitive determination of harmful alcohol use among hospitalized patients.

Indexed as

Alcohol DrinkingBiomarkersCross-Sectional StudiesFemaleGlycerophospholipidsHospitalsHumansMaleNorwayPredictive Value of TestsROC CurveRussiaSelf ReportBiomarkersGlycerophospholipidsphosphatidylethanol

Identifiers

PMID33677484
PMCPMC8557652
OpenAlexW3135674625

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.