Evidence map›Paper›PMID 33677235›Full record

ArticleTranslational oncology2021

Ascorbic acid analogue 6-Deoxy-6-[

Peng He, Bing Zhang, Yuan Zou, Yan Zhang, Zhihao Zha, Yali Long, Jia Qiu, Wanqing Shen, Xiaoping Lin, Zhoulei Li and 1 more

Open access · goldAbstract read
In one paragraph

Article in Translational oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. 6-Deoxy-6-[European radiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Vitamin-based radiopharmaceuticals for tumor imaging.Medical oncology (Northwood, London, England) · 2023
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Peng HeDepartment of Nuclear Medicine & Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
Bing ZhangDepartment of Nuclear Medicine & Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
Yuan ZouDepartment of Ultrasound Medicine & Ultrasonic Medical Engineering Key Laboratory of Nanchong City, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Yan ZhangDepartment of Physiology and Pathophysiology, Capital Medical University, Beijing 100069, China.
Zhihao ZhaDepartment of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Yali LongDepartment of Nuclear Medicine & Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
Jia QiuDepartment of Nuclear Medicine & Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
Wanqing ShenDepartment of Nuclear Medicine & Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
Xiaoping LinDepartment of Nuclear Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China,. Electronic address: linxp@sysucc.org.cn.
Zhoulei LiDepartment of Nuclear Medicine & Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China. Electronic address: lizhlei3@mail.sysu.edu.cn.
Xiangsong ZhangDepartment of Nuclear Medicine & Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China. Electronic address: zhxiangs@mail.sysu.edu.cn.
Sun Yat-sen University · CNCapital Medical University · CNNorth Sichuan Medical University · CNUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L-ascorbic acid (AA) was reported to have an anti-cancer effect over 40 years. In recent years, several ongoing clinical trials are exploring the safety and efficacy of intravenous high-dose AA for cancer treatment. The lack of appropriate imaging modality limits the identification of potentially suitable patients for AA treatment. This study focuses on identifying AA-sensitive tumor cells using molecular imaging. 6-Deoxy-6-[

Indexed as

(18)F-DFAColorectal cancerL-ascorbic acidPositron emission tomographySVCT2

Identifiers

PMID33677235
PMCPMC8046958
OpenAlexW3134317961

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.