Evidence map›Paper›PMID 33677050›Full record

ArticleInternational journal of radiation oncology, biology, physics2021

COVID-19 Vaccine-Induced Radiation Recall Phenomenon.

Viacheslav Soyfer, Orit Gutfeld, Sivan Shamai, Albert Schlocker, Ofer Merimsky

Open access · greenAbstract readCase Reports
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Radiation recall dermatitis in cancer patients previously undergoing radiotherapy: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. The Interplay of Lung Cancer, COVID-19, and Vaccines.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Viacheslav SoyferDepartment of Radiation Oncology, Division of Oncology, Tel-Aviv Medical Center, affiliated with Sackler School of Medicine, Tel-Aviv University. Electronic address: slavas2506@gmail.com.
Orit GutfeldDepartment of Radiation Oncology, Division of Oncology, Tel-Aviv Medical Center, affiliated with Sackler School of Medicine, Tel-Aviv University.
Sivan ShamaiUnit of Soft Tissue and Bone Oncology, Division of Oncology, Tel-Aviv Medical Center, affiliated with Sackler School of Medicine, Tel-Aviv University.
Albert SchlockerDepartment of Radiation Oncology, Division of Oncology, Tel-Aviv Medical Center, affiliated with Sackler School of Medicine, Tel-Aviv University.
Ofer MerimskyUnit of Soft Tissue and Bone Oncology, Division of Oncology, Tel-Aviv Medical Center, affiliated with Sackler School of Medicine, Tel-Aviv University.
Tel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation recall phenomenon (RRP) is an uncommon, late occurring, acute inflammatory skin reaction that emerges in localized areas coincident with previously irradiated radiation therapy (RT) treatment fields. RRP has been known to be triggered by a number of chemotherapy agents. To the best of our knowledge, this report is the first description of RRP after administration of the Pfizer-BioNTech vaccine for COVID-19, or any other currently available vaccine against COVID-19. Acute skin reactions were observed in 2 RT patients with differing timelines of RT and vaccinations. In both cases however, the RRP presented within days of the patient receiving the second dose of vaccine. For each RT course, the treatment planning dosimetry of the radiation fields was compared with the area of the observable RRP. RRP developed within the borders of treatment fields where prescription dose constraints were prioritized over skin sparing. Our observation is currently limited to 2 patients. The actual incidence of RRP in conjunction with Pfizer-BioNTech vaccine or any other vaccine against COVID-19 is unknown. For patients with cancer being treated with radiation with significant dose to skin, consideration should be given to the probability of RRP side effects from vaccinations against COVID-19.

Indexed as

AgedBNT162 VaccineCOVID-19 VaccinesHumansImmunization ScheduleImmunization, SecondaryLung NeoplasmsMaleMiddle AgedRadiodermatitisRadiosurgerySarcomaSkin NeoplasmsSpinal Cord CompressionThoracic WallBNT162 VaccineCOVID-19 Vaccines

Identifiers

PMID33677050
PMCPMC7930806
OpenAlexW3134339434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.