Evidence map›Paper›PMID 33676987›Full record

ArticleMolecular and cellular endocrinology2021

Granulosa cell genes that regulate ovarian follicle development beyond the antral stage: The role of estrogen receptor β.

V Praveen Chakravarthi, Anamika Ratri, Saeed Masumi, Shaon Borosha, Subhra Ghosh, Lane K Christenson, Katherine F Roby, Michael W Wolfe, M A Karim Rumi

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 53 citations in OpenAlex.

  1. Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra-Nuclear Signaling to Modulate Human Granulosa Cell Growth.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Quercetin attenuates nicotine-induced ovarian and uterine dysfunction in rats.Clinical and experimental reproductive medicine · 2026
    Article
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  19. The epithelial NaCell communication and signaling : CCS · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

V Praveen ChakravarthiDepartment of Pathology and Laboratory Medicine, Kansas City, KS, USA.
Anamika RatriDepartment of Molecular and Integrative Physiology, Kansas City, KS, USA.
Saeed MasumiDepartment of Pathology and Laboratory Medicine, Kansas City, KS, USA.
Shaon BoroshaDepartment of Pathology and Laboratory Medicine, Kansas City, KS, USA.
Subhra GhoshDepartment of Pathology and Laboratory Medicine, Kansas City, KS, USA.
Lane K ChristensonDepartment of Molecular and Integrative Physiology, Kansas City, KS, USA; Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, KS, USA.
Katherine F RobyDepartment of Anatomy and Cell Biology, Kansas City, KS, USA; Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, KS, USA.
Michael W WolfeDepartment of Molecular and Integrative Physiology, Kansas City, KS, USA; Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, KS, USA.
M A Karim RumiDepartment of Pathology and Laboratory Medicine, Kansas City, KS, USA; Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: mrumi@kumc.edu.
The University of Kansas Health System · USUniversity of Kansas Medical Center · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Molecular Regulation of Cell Development and Differentiation Phase III COBREP30GM122731 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ABRAHAMSON, DALE R · 2017 to 2021
$5.6M
NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P30 GM122731
6 · The paper itself

Abstract

Follicle development beyond the preantral stage is dependent on gonadotropins. FSH signaling is crucial for the advancement of preantral follicles to the antral stage, and LH signaling is essential for further maturation of preovulatory follicles. Estrogen is intricately tied to gonadotropin signaling during the advanced stages of folliculogenesis. We observed that Erβ

Indexed as

AnimalsChorionic GonadotropinEstrogen Receptor betaFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksGranulosa CellsHigh-Throughput Nucleotide SequencingLoss of Function MutationOvarian FollicleRatsSequence Analysis, RNAChorionic GonadotropinEstrogen Receptor betaERβFollicle maturationGonadotropinsGranulosa cellsTranscriptome analyses

Identifiers

PMID33676987
PMCPMC8916094
OpenAlexW3135087968

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.