Evidence map›Paper›PMID 33676895›Full record

ArticleThe Journal of biological chemistry

Rab43 GTPase directs postsynaptic trafficking and neuron-specific sorting of G protein-coupled receptors.

Zhe Wei, Xin Xu, Yinquan Fang, Mostafa Khater, Sean X Naughton, Gang Hu, Alvin V Terry, Guangyu Wu

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Elucidating the molecular interplay between LRRK2 and Rab GTPases.bioRxiv : the preprint server for biology · 2026
    Article
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  11. Human C1orf27 protein interacts with αThe Journal of biological chemistry · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Zhe WeiDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Xin XuDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Yinquan FangDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA; Department of Pharmacology, Nanjing Medical University, Nanjing, China.
Mostafa KhaterDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Sean X NaughtonDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Gang HuDepartment of Pharmacology, Nanjing Medical University, Nanjing, China.
Alvin V TerryDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Guangyu WuDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA. Electronic address: guwu@augusta.edu.
Augusta University · USNanjing Medical University · CN

Funding

GPCR anterograde traffickingR35GM136397 · NIGMS · AUGUSTA UNIVERSITY · PI GUANGYU WU · 2020 to 2026
$2.7M
Anterograde transport and signal regulation of GPCRsR01GM118915 · NIGMS · AUGUSTA UNIVERSITY · PI WU, GUANGYU · 2016 to 2019
$1.3M
NIGMS NIH HHS R01 GM118915NIGMS NIH HHS R35 GM136397
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) are important modulators of synaptic functions. A fundamental but poorly addressed question in neurobiology is how targeted GPCR trafficking is achieved. Rab GTPases are the master regulators of vesicle-mediated membrane trafficking, but their functions in the synaptic presentation of newly synthesized GPCRs are virtually unknown. Here, we investigate the role of Rab43, via dominant-negative inhibition and CRISPR-Cas9-mediated KO, in the export trafficking of α

Indexed as

Synaptic TransmissionAnimalsCell MembraneEndoplasmic ReticulumGolgi ApparatusHEK293 CellsHumansNeuronsProtein Transportrab11 GTP-Binding Proteinsrab GTP-Binding ProteinsRatsRats, Sprague-DawleyReceptors, G-Protein-Coupledrab11 GTP-Binding Proteinsrab GTP-Binding ProteinsReceptors, G-Protein-CoupleddendriteG protein-coupled receptormuscarinic acetylcholine receptorneuronRab43Rab GTPasesortingsynapsetraffickingα(2)-adrenergic receptor

Identifiers

PMID33676895
PMCPMC8050390
OpenAlexW3133655105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.