Evidence map›Paper›PMID 33676784›Full record

ArticleVaccine2021

A validated modification of the vaccine hesitancy scale for childhood, influenza and HPV vaccines.

Laura J Helmkamp, Peter G Szilagyi, Gregory Zimet, Alison W Saville, Dennis Gurfinkel, Christina Albertin, Abigail Breck, Sitaram Vangala, Allison Kempe

Abstract read
In one paragraph

Article in Vaccine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 71 citations in OpenAlex.

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  5. What do parents of school-aged children want to know about HPV vaccination in Canada? Results of an online survey on Facebook.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Laura J HelmkampAdult and Child Consortium for Health Outcomes Research and Delivery Science (ACCORDS), University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, United States. Electronic address: Laura.Helmkamp@CUAnschutz.edu.
Peter G SzilagyiDepartment of Pediatrics, UCLA Mattel Children's Hospital, University of California at Los Angeles, Los Angeles, CA, United States. Electronic address: PSzilagyi@mednet.ucla.edu.
Gregory ZimetDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address: gzimet@iu.edu.
Alison W SavilleAdult and Child Consortium for Health Outcomes Research and Delivery Science (ACCORDS), University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, United States. Electronic address: Alison.saville@CUAnschutz.edu.
Dennis GurfinkelAdult and Child Consortium for Health Outcomes Research and Delivery Science (ACCORDS), University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, United States. Electronic address: Dennis.gurfinkel@CUAnschutz.edu.
Christina AlbertinDepartment of Pediatrics, UCLA Mattel Children's Hospital, University of California at Los Angeles, Los Angeles, CA, United States. Electronic address: Christina.albertin@urmc.rochester.edu.
Abigail BreckDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States. Electronic address: Abreck@mednet.ucla.edu.
Sitaram VangalaDepartment of Pediatrics, UCLA Mattel Children's Hospital, University of California at Los Angeles, Los Angeles, CA, United States. Electronic address: SVangala@mednet.ucla.edu.
Allison KempeAdult and Child Consortium for Health Outcomes Research and Delivery Science (ACCORDS), University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, United States; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States. Electronic address: Allison.kempe@childrenscolorado.org.
University of Colorado Denver · USMattel Children's Hospital · USIndiana University School of MedicineUniversity of California, Los Angeles · US

Funding

The HPV9-10 Trial: Early Initiation of HPV VaccinationR01CA240649 · NCI · UNIVERSITY OF COLORADO DENVER · PI KEMPE, ALLISON, SZILAGYI, PETER G · 2020 to 2024
$3.2M
Centralized IIS-Based Reminder-Recall to Increase Influenza Vaccination RatesR01AI114903 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KEMPE, ALLISON, SZILAGYI, PETER G · 2015 to 2018
$2.8M
State Immunization Information Systems to Improve HPV Vaccination RatesR01CA187707 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KEMPE, ALLISON, SZILAGYI, PETER G · 2015 to 2018
$2.4M
NCI NIH HHS R01 CA187707NCI NIH HHS R01 CA240649NIAID NIH HHS R01 AI114903
6 · The paper itself

Abstract

introductionVaccine hesitancy contributes to outbreaks of preventable disease worldwide. The Vaccine Hesitancy Scale (VHS), developed by the international WHO SAGE Working Group, has been validated previously for measuring hesitancy towards childhood vaccines; some psychometric properties were suboptimal.

methodsWe collected data using large, nationally-representative samples of parents in the U.S. We adapted the VHS items, and additional hesitancy items, to assess hesitancy towards influenza and HPV vaccines in addition to routine childhood vaccines. We then used exploratory and confirmatory factor analysis to identify latent constructs and create modified scales for childhood (VHS-child), influenza (VHS-flu) and HPV (VHS-HPV) vaccines with improved psychometric properties. Finally, we compared hesitancy scores on the VHS-child, VHS-flu, and VHS-HPV, to self-reported receipt of each vaccine category, and compared subscale scores to assess whether drivers of hesitancy differed by vaccine category.

results2052 parents of children <18 years old completed the VHS-child and VHS-flu while 2020 parents of adolescents completed the VHS-HPV. A two-factor structure of 'risks' and a 'lack of confidence' was found for each vaccine category. Slight modifications to the VHS improved psychometric properties. Hesitancy was strongly associated with vaccine receipt: e.g., 76% of parents not hesitant towards influenza vaccine had vaccinated their child the past season, versus 9% of hesitant parents (p < 0.0001). Subscale scores also differed significantly between vaccines: lack of confidence was greater towards influenza (Median (IQR): 2.0 (1.2, 3.3)) and HPV (2.0 (1.3, 3.0)) vaccines than childhood (1.2 (1.0, 1.8), p < 0.0001 for both) vaccines; perceived risks of HPV vaccines (2.7 (1.7, 3.7)) were greater than for childhood vaccines (2.0 (1.3, 3.0), p < 0.0001).

conclusionsOur modified VHS scales perform well psychometrically and allow for consistent measurement of the extent and reasons for hesitancy between vaccine categories. We suggest that future work use these scales to examine hesitancy towards other vaccines and to monitor hesitancy over time.

Indexed as

Influenza, HumanInfluenza VaccinesPapillomavirus VaccinesAdolescentChildHealth Knowledge, Attitudes, PracticeHumansParentsPatient Acceptance of Health CareVaccinationInfluenza VaccinesPapillomavirus VaccinesChildhood vaccinesFactor analysisHesitancyHPV vaccineInfluenza vaccineVaccine Hesitancy Scale (VHS)

Identifiers

PMID33676784
PMCPMC13325669
OpenAlexW3134345905

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.