ArticleBMC veterinary research2021
Differences in the gut microbiomes of dogs and wolves: roles of antibiotics and starch.
Article in BMC veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Next-Generation Sequencing Insights into the Oral Microbiome and Antibiotic Resistance Genes in Grey Wolves (Animals : an open access journal from MDPI · 2025Article
- Reference Whole Genome Sequence Analyses and Characterization of a NovelVeterinary sciences · 2025Article
- Captive environments reshape the compositions of carbohydrate active enzymes and virulence factors in wolf gut microbiome.BMC microbiology · 2025Article
- The fecal metabolomic signature of a plant-based (vegan) diet compared to an animal-based diet in healthy adult client-owned dogs.Journal of animal science · 2025Article
- Effects of diet type on the core fecal bacterial taxa and the dysbiosis index of healthy adult dogs.Frontiers in veterinary science · 2025Article
- Article
- Comprehensive profile of the companion animal gut microbiome integrating reference-based and reference-free methods.The ISME journal · 2024Article
- Comparison of the fecal microbiota of adult healthy dogs fed a plant-based (vegan) or an animal-based diet.Frontiers in microbiology · 2024Article
- Achieving pan-microbiome biological insights via the dbBact knowledge base.Nucleic acids research · 2023Article
- Virulence-related factors and antimicrobial resistance inFrontiers in microbiology · 2023Article
- The effects of antibiotics and illness on gut microbial composition in the fawn-footed mosaic-tailed rat (Melomys cervinipes).PloS one · 2023Article
- Antimicrobial resistance-Do we share more than companionship with our dogs?Journal of applied microbiology · 2022Article
- The Australian dingo is an early offshoot of modern breed dogs.Science advances · 2022Article
- Gut microbiome of captive wolves is more similar to domestic dogs than wild wolves indicated by metagenomics study.Frontiers in microbiology · 2022Article
- Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundDogs are domesticated wolves. Change of living environment, such as diet and veterinary care may affect the gut bacterial flora of dogs. The aim of this study was to assess the gut bacterial diversity and function in dogs compared with captive wolves. We surveyed the gut bacterial diversity of 27 domestic dogs, which were fed commercial dog food, and 31 wolves, which were fed uncooked meat, by 16S rRNA sequencing. In addition, we collected fecal samples from 5 dogs and 5 wolves for shotgun metagenomic sequencing to explore changes in the functions of their gut microbiome.
resultsDifferences in the abundance of core bacterial genera were observed between dogs and wolves. Together with shotgun metagenomics, the gut microbiome of dogs was found to be enriched in bacteria resistant to clinical drugs (P < 0.001), while wolves were enriched in bacteria resistant to antibiotics used in livestock (P < 0.001). In addition, a higher abundance of putative α-amylase genes (P < 0.05; P < 0.01) was observed in the dog samples.
conclusionsLiving environment of dogs and domestic wolves has led to increased numbers of bacteria with antibiotic resistance genes, with exposure to antibiotics through direct and indirect methods. In addition, the living environment of dogs has allowed the adaptation of their microbiota to a starch-rich diet. These observations align with a domestic lifestyle for domestic dogs and captive wolves, which might have consequences for public health.
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