Evidence map›Paper›PMID 33676419›Full record

ArticleBMC genomics2021

Key metabolism pathways and regulatory mechanisms of high polysaccharide yielding in Hericium erinaceus.

Ming Gong, Henan Zhang, Di Wu, Zhong Zhang, Jinsong Zhang, Dapeng Bao, Yan Yang

Open access · goldAbstract read
In one paragraph

Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Regional Cultivation Forms ofJournal of fungi (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Review
  5. Breeding of High-Polysaccharide-ProducingJournal of fungi (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Lion's Mane Mushroom (Nutrients · 2025
    Review
  9. Article
  10. Different Symbiotic Species ofMicroorganisms · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Characterization and Heterologous Expression of UDP-Glucose 4-Epimerase From aFrontiers in bioengineering and biotechnology · 2021
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ming Gong *Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, the People's Republic of China, No.1000, Jinqi Road, Shanghai, 201403, China.
Henan Zhang *Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, the People's Republic of China, No.1000, Jinqi Road, Shanghai, 201403, China.
Di WuInstitute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, the People's Republic of China, No.1000, Jinqi Road, Shanghai, 201403, China.
Zhong ZhangInstitute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, the People's Republic of China, No.1000, Jinqi Road, Shanghai, 201403, China.
Jinsong ZhangInstitute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, the People's Republic of China, No.1000, Jinqi Road, Shanghai, 201403, China.
Dapeng BaoInstitute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, the People's Republic of China, No.1000, Jinqi Road, Shanghai, 201403, China.
Yan YangInstitute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, the People's Republic of China, No.1000, Jinqi Road, Shanghai, 201403, China. yangyan@saas.sh.cn.ORCID http://orcid.org/0000-0003-1421-8003
Shanghai Academy of Agricultural Sciences · CN

Funding

Shanghai Leading Academic Discipline Project 2018Shanghai Science and Technology Development Foundation Key R&D projects:18391903500
6 · The paper itself

Abstract

backgroundHericium erinaceus, a rare edible and medicine fungus, is widely used in the food and medical field. Polysaccharides from H. erinaceus are the main bioactive compound that exert high bioactive value in the medical and healthcare industries.

resultsThe genome of H. erinaceus original strain HEA was reported 38.16 Mb, encoding 9780 predicted genes by single-molecule, real-time sequencing technology. The phylogenomic analysis showed that H. erinaceus had the closest evolutionary affinity with Dentipellis sp. The polysaccharide content in the fermented mycelia of mutated strains HEB and HEC, which obtained by ARTP mutagenesis in our previous study, was improved by 23.25 and 47.45%, and a new β-glucan fraction with molecular weight 1.056 × 10

conclusionsThe study revealed the primary mechanism of the increased polysaccharide synthesis induced by ARTP mutagenesis and explored the essential genes and pathways of polysaccharide synthesis.

Indexed as

BasidiomycotaHericiumMolecular WeightMyceliumPolysaccharidesPolysaccharidesARTP mutagenesisCarbohydrate metabolismHericium erinaceusHigh polysaccharide yieldRAS-cAMP-PKA pathway

Identifiers

PMID33676419
PMCPMC7937317
OpenAlexW3112388779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.