ArticleCerebral cortex (New York, N.Y. : 1991)2021
Comparative Ultrastructural Analysis of Thalamocortical Innervation of the Primary Motor Cortex and Supplementary Motor Area in Control and MPTP-Treated Parkinsonian Monkeys.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Calcitonin Gene-Related Peptide (CGRP)-Containing Terminals in the Central Amygdala of Mice and Monkeys: Ultrastructural Analysis and Subsynaptic Expression of GluD1.The European journal of neuroscience · 2026Article
- Emergence of Task-Related Motor Cortical Dysfunction in Mice with Progressive Parkinsonism.bioRxiv : the preprint server for biology · 2026Article
- Parkinsonism disrupts the balance between excitatory and inhibitory activity within the primary motor cortex during movement.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Enhanced beta power emerges from simulated parkinsonian primary motor cortex.NPJ Parkinson's disease · 2025Article
- Movement-related activity in the internal globus pallidus of the parkinsonian macaque.Journal of neurophysiology · 2025Article
- Enhanced beta power emerges from simulated parkinsonian primary motor cortex.bioRxiv : the preprint server for biology · 2025Article
- Parkinsonism disrupts cortical function by dysregulating oscillatory, network and synaptic activity of parvalbumin positive interneurons.NPJ Parkinson's disease · 2025Article
- Single pulse electrical stimulation of the medial thalamic surface induces narrower high gamma band activities in the sensorimotor cortex.Scientific reports · 2025Article
- Motor cortical circuit adaptations in parkinsonism.Neural regeneration research · 2024Article
- Dysfunction of motor cortices in Parkinson's disease.Cerebral cortex (New York, N.Y. : 1991) · 2024Review
- Reduced thalamic excitation to motor cortical pyramidal tract neurons in parkinsonism.Science advances · 2023Article
- Cell Type-Specific Decrease of the Intrinsic Excitability of Motor Cortical Pyramidal Neurons in Parkinsonism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The synaptic organization of thalamic inputs to motor cortices remains poorly understood in primates. Thus, we compared the regional and synaptic connections of vGluT2-positive thalamocortical glutamatergic terminals in the supplementary motor area (SMA) and the primary motor cortex (M1) between control and MPTP-treated parkinsonian monkeys. In controls, vGluT2-containing fibers and terminal-like profiles invaded layer II-III and Vb of M1 and SMA. A significant reduction of vGluT2 labeling was found in layer Vb, but not in layer II-III, of parkinsonian animals, suggesting a potential thalamic denervation of deep cortical layers in parkinsonism. There was a significant difference in the pattern of synaptic connectivity in layers II-III, but not in layer Vb, between M1 and SMA of control monkeys. However, this difference was abolished in parkinsonian animals. No major difference was found in the proportion of perforated versus macular post-synaptic densities at thalamocortical synapses between control and parkinsonian monkeys in both cortical regions, except for a slight increase in the prevalence of perforated axo-dendritic synapses in the SMA of parkinsonian monkeys. Our findings suggest that disruption of the thalamic innervation of M1 and SMA may underlie pathophysiological changes of the motor thalamocortical loop in the state of parkinsonism.
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