Evidence map›Paper›PMID 33676146›Full record

ArticleJournal of the neurological sciences2021

Abnormal movements in hospitalized COVID-19 patients: A case series.

Jeffrey R Clark, Eric M Liotta, Nicholas J Reish, Nathan A Shlobin, Steven C Hoffman, Zachary S Orban, Patrick H Lim, Igor J Koralnik, Ayush Batra

Open access · bronzeAbstract readVideo-Audio Media
In one paragraph

Article in Journal of the neurological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Movement Disorders and SARS-CoV-2.Movement disorders clinical practice · 2023
    Article
  3. Review
  4. Therapeutic Approaches to the Neurologic Manifestations of COVID-19.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
  5. Review
  6. Clinical heterogeneity in patients with myoclonus associated to COVID-19.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jeffrey R ClarkKen & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Eric M LiottaKen & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Nicholas J ReishKen & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Nathan A ShlobinKen & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Steven C HoffmanKen & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Zachary S OrbanKen & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Patrick H LimKen & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Igor J KoralnikKen & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Ayush BatraKen & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America. Electronic address: Ayush.Batra@northwestern.edu.
Northwestern University · US

Funding

Chicago Stroke Trials ConsortiumU24NS107233 · NINDS · UNIVERSITY OF CHICAGO · PI Shyam Prabhakaran · 2018 to 2026
$2.8M
NINDS NIH HHS L30 NS098427NINDS NIH HHS U24 NS107233
6 · The paper itself

Abstract

backgroundAbnormal movements in Covid-19 patients have been reported with varying degree of frequency, prompting neurologic consultation and additional diagnostic evaluation. We sought to evaluate the frequency and etiology of abnormal movements among hospitalized Covid-19 patients undergoing neurologic consultation.

methodsWe retrospectively analyzed the first 50 consecutive patients with confirmed Covid-19 hospitalized at our tertiary medical care center who underwent acute inpatient neurology consultation from March 2020 through May 2020. Indication for neurologic consultation and diagnostic studies performed were identified by electronic medical record review.

resultsOf the 50 initial consultation requests, 11 (22.0%) patients were evaluated for abnormal movements (nine male and two female). Myoclonus was diagnosed in 6/11 (54.5%) patients. Additionally, two patients were diagnosed with seizures (confirmed on EEG in one), while two additional patients were diagnosed with tremor (physiologic and probable functional). A single case of serotonin syndrome was also identified.

conclusionAbnormal movements observed in hospitalized Covid-19 patients can have a wide range of etiologies and were a frequent initial indication for neurologic consultation. Myoclonus was the most frequent type of abnormal movement observed. Early clinical recognition and directed diagnostic work-up is essential for accurate diagnoses in these patients.

Indexed as

AdultAgedCOVID-19COVID-19 TestingDyskinesiasFemaleHumansMaleMiddle AgedMyoclonusRetrospective StudiesSARS-CoV-2SeizuresSerotonin SyndromeTertiary Care CentersTremorCOVID-19Movement disorderMyoclonusSeizureSerotonin syndromeTremor

Identifiers

PMID33676146
PMCPMC7908881
OpenAlexW3134725423

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.