Evidence map›Paper›PMID 33676119›Full record

ArticleRespiratory medicine2021

A comprehensive assessment of environmental exposures and the medical history guides multidisciplinary discussion in interstitial lung disease.

Neal Dodia, Diana Amariei, Blaine Kenaa, Doug Corwin, Lydia Chelala, E James Britt, Ashutosh Sachdeva, Irina G Luzina, Jeffrey D Hasday, Nirav G Shah and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Neal DodiaDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Diana AmarieiDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Blaine KenaaDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Doug CorwinDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Lydia ChelalaDepartment of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, MD, USA.
E James BrittDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Ashutosh SachdevaDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Irina G LuzinaDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA.
Jeffrey D HasdayDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA.
Nirav G ShahDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Sergei P AtamasDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA.
Teri J FranksDepartment of Defense, The Joint Pathology Center, USA.
Allen P BurkeDepartment of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
Stella E HinesDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Jeffrey R GalvinDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Nevins W ToddDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA. Electronic address: ntodd@som.umaryland.edu.
University of Maryland, Baltimore · USUnited States Department of Defense · US

Funding

The Mechanisms of Profibrotic Sensitization by IL33R01HL126897 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LUZINA, IRINA G. · 2015 to 2018
$1.4M
The Central Role of IL-33 in Immune-Mediated ScarringI01BX002499 · VA · BALTIMORE VA MEDICAL CENTER · PI LUZINA, IRINA G. · 2015 to 2020
–
Integrin-dependent mechanism of T cell-mediated pulmonary fibrosisI01CX000101 · VA · BALTIMORE VA MEDICAL CENTER · PI LUZINA, IRINA G. · 2009 to 2017
–
BLRD VA I01 BX002499CSRD VA I01 CX000101NHLBI NIH HHS R01 HL126897
6 · The paper itself

Abstract

backgroundMultidisciplinary discussion (MDD) is widely recommended for patients with interstitial lung disease (ILD), but published primary data from MDD has been scarce, and factors influencing MDD other than chest computed tomography (CT) and lung histopathology interpretations have not been well-described.

methodsSingle institution MDD of 179 patients with ILD.

resultsMDD consensus clinical diagnoses included autoimmune-related ILD, chronic hypersensitivity pneumonitis, smoking-related ILD, idiopathic pulmonary fibrosis, medication-induced ILD, occupation-related ILD, unclassifiable ILD, and a few less common pulmonary disorders. In 168 of 179 patients, one or more environmental exposures or pertinent features of the medical history were identified, including recreational/avocational, residential, and occupational exposures, systemic autoimmune disease, malignancy, medication use, and family history. The MDD process demonstrated the importance of comprehensively assessing these exposures and features, beyond merely noting their presence, for rendering consensus clinical diagnoses. Precise, well-defined chest CT and lung histopathology interpretations were rendered at MDD, including usual interstitial pneumonia, nonspecific interstitial pneumonia, and organizing pneumonia, but these interpretations were associated with a variety of MDD consensus clinical diagnoses, demonstrating their nonspecific nature in many instances. In 77 patients in which MDD consensus diagnosis differed from referring diagnosis, assessment of environmental exposures and medical history was found retrospectively to be the most impactful factor.

conclusionsA comprehensive assessment of environmental exposures and pertinent features of the medical history guided MDD. In addition to rendering consensus clinical diagnoses, MDD presented clinicians with opportunities to initiate environmental remediation, behavior modification, or medication alteration likely to benefit individual patients with ILD.

Indexed as

ConsensusInterdisciplinary CommunicationLung Diseases, InterstitialMedical History TakingAgedAutoimmune DiseasesEnvironmental ExposureFemaleHumansLungMaleMiddle AgedOccupational ExposureRisk FactorsSmokingTomography, X-Ray ComputedAutoimmuneHypersensitivityIdiopathic pulmonary fibrosisInterstitial lung diseaseMultidisciplinary discussionOccupationSmoking

Identifiers

PMID33676119
PMCPMC7992253
OpenAlexW3126765649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.