Evidence map›Paper›PMID 33676074›Full record

ArticleDrug and alcohol dependence2021

Characterization of alcohol polygenic risk scores in the context of mental health outcomes: Within-individual and intergenerational analyses in the Avon Longitudinal Study of Parents and Children.

Kayleigh E Easey, Robyn E Wootton, Hannah M Sallis, Elis Haan, Laura Schellhas, Marcus R Munafò, Nicholas J Timpson, Luisa Zuccolo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kayleigh E EaseyMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Department of Population Health Sciences, Bristol Medical School, University of Bristol, UK. Electronic address: kayleigh.easey@bristol.ac.uk.
Robyn E WoottonMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Department of Population Health Sciences, Bristol Medical School, University of Bristol, UK.
Hannah M SallisMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Department of Population Health Sciences, Bristol Medical School, University of Bristol, UK; School of Psychological Science, University of Bristol, Bristol, UK; Centre for Academic Mental Health, Bristol Medical School, University of Bristol, UK.
Elis HaanMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; School of Psychological Science, University of Bristol, Bristol, UK.
Laura SchellhasMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; School of Psychological Science, University of Bristol, Bristol, UK.
Marcus R MunafòMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; School of Psychological Science, University of Bristol, Bristol, UK.
Nicholas J TimpsonMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Department of Population Health Sciences, Bristol Medical School, University of Bristol, UK.
Luisa ZuccoloMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Department of Population Health Sciences, Bristol Medical School, University of Bristol, UK.
University of Bristol · GB

Funding

Cancer Research UK C18281/A19169Medical Research Council G0902144Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/7Medical Research Council MC_UU_12013/1Medical Research Council MR/L022206/1Medical Research Council MR/L033306/1Wellcome TrustWellcome Trust 102215/2/13/2Wellcome Trust 202802/Z/16/Z
6 · The paper itself

Abstract

backgroundHeavy alcohol consumption often co-occurs with mental health problems; this could be due to confounding, shared biological mechanisms, or causal effects. Polygenic risk scores (PRS) for alcohol use can be used to explore this association at critical life stages.

designWe characterized a PRS reliably associated with patterns of adult alcohol consumption by 1) validating whether it predicts own alcohol use at different life-stages (pregnancy, adolescence) of interest for mental health impact. Additionally, we explored associations of alcohol PRS on mental health phenotypes 2) within-individuals (using own alcohol PRS on own phenotypes) and 3) intergenerationally (using maternal alcohol PRS on offspring phenotypes). We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) (n = 960-7841). Additional substance abuse behaviors and mental health/behavioral outcomes were investigated (alcohol phenotypes n = 22; health phenotypes n = 91).

findingsMaternal alcohol PRS was associated with consumption during pregnancy (strongest signal: alcohol frequency at 18 weeks' gestation: β = 0.041, 95%CI = 0.0.02-0.06), p = 1.01 × 10

conclusionsThese alcohol PRS are a valid proxy for maternal alcohol use in pregnancy. Offspring alcohol PRS was not associated with drinking in adolescence. Consistently with results from different study designs, we found evidence that maternal alcohol PRS are associated with both prenatal depression and decreased offspring intellectual ability.

Indexed as

Mental HealthAdolescentAdultAlcohol DrinkingChildChild, PreschoolDepressionFemaleHumansIntergenerational RelationsLongitudinal StudiesMaleMaternal HealthMultifactorial InheritanceParentsPregnancyAlcoholALSPACMental healthMR-PheWASPolygenic risk score

Identifiers

PMID33676074
PMCPMC8047864
OpenAlexW3134167082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.