Evidence map›Paper›PMID 33676006›Full record

ReviewProgress in retinal and eye research2021

Human limbal epithelial stem cell regulation, bioengineering and function.

Clémence Bonnet, Sheyla González, JoAnn S Roberts, Sarah Y T Robertson, Maxime Ruiz, Jie Zheng, Sophie X Deng

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in retinal and eye research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 108 citations in OpenAlex.

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  18. Accumulation of Epigenetic Noise in the Aging Corneal Epithelium and Its Possible Mechanism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Clémence BonnetCornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA; Cornea Department, Paris University, Cochin Hospital, AP-HP, F-75014, Paris, France.
Sheyla GonzálezCornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA.
JoAnn S RobertsCornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA.
Sarah Y T RobertsonCornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA.
Maxime RuizCornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA.
Jie ZhengBasic Science Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA.
Sophie X DengCornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA. Electronic address: deng@jsei.ucla.edu.
University of California, Los Angeles · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xian-Jie Yang · 1985 to 2026
$16.8M
Ex Vivo Expansion of Human Limbal Stem Cells for TransplantationR01EY021797 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sophie Deng · 2012 to 2026
$5.1M
Development of small-molecule Wnt mimetics for corneal epithelial cell regenerationR01EY028557 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DENG, SOPHIE, ZHENG, JIE J. · 2018 to 2021
$2.0M
NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY021797NEI NIH HHS R01 EY028557
6 · The paper itself

Abstract

The corneal epithelium is continuously renewed by limbal stem/progenitor cells (LSCs), a cell population harbored in a highly regulated niche located at the limbus. Dysfunction and/or loss of LSCs and their niche cause limbal stem cell deficiency (LSCD), a disease that is marked by invasion of conjunctival epithelium into the cornea and results in failure of epithelial wound healing. Corneal opacity, pain, loss of vision, and blindness are the consequences of LSCD. Successful treatment of LSCD depends on accurate diagnosis and staging of the disease and requires restoration of functional LSCs and their niche. This review highlights the major advances in the identification of potential LSC biomarkers and components of the LSC niche, understanding of LSC regulation, methods and regulatory standards in bioengineering of LSCs, and diagnosis and staging of LSCD. Overall, this review presents key points for researchers and clinicians alike to consider in deepening the understanding of LSC biology and improving LSCD therapies.

Indexed as

Corneal DiseasesEpithelium, CornealLimbus CorneaeBioengineeringHumansStem CellsAnterior segment coherence tomographyCell therapyIn vivo laser scanning confocal microscopyLimbal stem cellLimbal stem cell deficiencyNotch signaling pathwaySmall moleculesWnt signaling pathway

Identifiers

PMID33676006
PMCPMC8428188
OpenAlexW3135011529

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.