ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021
Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital.
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Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
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- Association between glucocorticoids treatment and viral clearance delay in patients with COVID-19: a systematic review and meta-analysis.BMC infectious diseases · 2021Pooled it
- Exploring the Relationship Between Comorbidities and Prolonged Viral Shedding in COVID-19: A Cycle Threshold Value-Based Investigation.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026Article
- Plasmablastic Lymphoma. A State-of-the-Art Review: Part 2-Focus on Therapy.Mediterranean journal of hematology and infectious diseases · 2024Review
- Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Vaccination for Negative Conversion Time of Nucleic Acid in Nonsevere COVID-19 Patients Infected by SARS-CoV-2 Omicron Variant.International journal of clinical practice · 2023Article
- The impacts of vaccination status and host factors during early infection on SARS-CoV-2 persistence:a retrospective single-center cohort study.International immunopharmacology · 2023Article
- SARS-CoV-2 quasi-species analysis from patients with persistent nasopharyngeal shedding.Scientific reports · 2022Article
- Prolonged fever and exaggerated hypercoagulopathy in malaria vivax relapse and COVID-19 co-infection: a case report.Malaria journal · 2022Article
- New endemic and pandemic pathologies with interhuman airborne transmission through ear, nose and throat anatomical sites.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2022Article
- Impact of Remdesivir on SARS-CoV-2 Clearance in a Real-Life Setting: A Matched-Cohort Study.Drug design, development and therapy · 2022Article
- Influence of Fasting Plasma Glucose Level on Admission of COVID-19 Patients: A Retrospective Study.Journal of diabetes research · 2022Article
- Clinical characteristics and clinical outcome of community clusters with SARS-CoV-2 infection.Frontiers in public health · 2022Article
- Common Variable Immunodeficiency Disorders, T-Cell Responses to SARS-CoV-2 Vaccines, and the Risk of Chronic COVID-19.The journal of allergy and clinical immunology. In practice · 2021Article
- Smoking and COVID-19 Infection and Related Mortality: A Prospective Cohort Analysis of UK Biobank Data.Clinical epidemiology · 2021Article
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Authors and funding
207 authors at 2 institutions in 1 country.
Annalisa MondiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Patrizia LorenziniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Concetta CastillettiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Roberta GagliardiniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy. Electronic address: roberta.gagliardini@inmi.it.
Eleonora LalleNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Angela CorpolongoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria Beatrice ValliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Fabrizio TagliettiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Stefania CicaliniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Laura LoiaconoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Francesco Di GennaroNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Gianpiero D'OffiziNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Fabrizio PalmieriNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Emanuele NicastriNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Chiara AgratiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Nicola PetrosilloNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Giuseppe IppolitoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Francesco VaiaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Enrico GirardiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria Rosaria CapobianchiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Andrea AntinoriNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Sara ZitoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria Alessandra AbbonizioNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Amina AbdeddaimNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Elisabetta AgostiniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Chiara AgratiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Fabrizio AlbarelloNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Gioia AmadeiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Alessandra AmendolaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Andrea AntinoriNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria Assunta AntonicaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Mario AntoniniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Tommaso Ascoli BartoliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Francesco BaldiniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Raffaella BarbaroNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Barbara BartoliniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Rita BellagambaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Martina BenigniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Nazario BevilacquaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Gianluigi BiavaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Michele BibasNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Licia BordiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Veronica BordoniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Evangelo BoumisNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Marta BrancaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Rosanna BuonomoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Donatella BussoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Marta CamiciNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Paolo CampioniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Flaminia CanichellaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria Rosaria CapobianchiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Alessandro CaponeNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Cinzia CaporaleNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Emanuela CaraffaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Ilaria CaravellaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Fabrizio CarlettiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Concetta CastillettiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Adriana CataldoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Stefano CerilliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Carlotta CervaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Roberta ChiappiniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Pierangelo ChinelloNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria Assunta CianfaraniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Carmine CiaralliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Claudia CimagliaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Nicola CinicolaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Veronica CiottiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Stefania CicaliniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Francesca ColavitaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Angela CorpolongoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Massimo CristofaroNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Salvatore CurialeNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Alessandra D'AbramoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Cristina DantimiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Alessia De AngelisNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Giada De AngelisNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria Grazia De PaloNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Federico De ZottisNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Virginia Di BariNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Rachele Di LorenzoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Federica Di StefanoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Gianpiero D'OffiziNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Davide DonnoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Francesca EvangelistaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Francesca FaragliaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Anna FarinaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Federica FerraroNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Lorena FiorentiniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Andrea FrustaciNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Matteo FusettiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Vincenzo GalatiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Roberta GagliardiniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Paola GallìNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Gabriele GarottoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Ilaria GavianoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Saba Gebremeskel TekleNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria Letizia GiancolaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Filippo GiansanteNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Emanuela GiombiniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Guido GranataNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria Cristina GreciNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Elisabetta GrilliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Susanna GrisettiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Gina GualanoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Fabio IacomiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Marta IaconiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Giuseppina IannicelliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Carlo InversiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Giuseppe IppolitoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Eleonora LalleNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria Elena LamannaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Simone LaniniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Daniele LapaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Luciana LeporeNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Raffaella LibertoneNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Raffaella LionettiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Giuseppina LiuzziNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Laura LoiaconoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Andrea LuciaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Franco LufraniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Manuela MacchioneNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Gaetano MaffongelliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Alessandra MaraniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Luisa MarchioniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Andrea MarianoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria Cristina MariniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Micaela MarittiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Annelisa MastrobattistaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Ilaria MastrorosaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Giulia MatusaliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Valentina MazzottaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Paola MencariniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Silvia MeschiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Francesco MessinaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Sibiana MicarelliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Giulia MogaveroNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Annalisa MondiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Marzia MontalbanoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Chiara MontaldoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Silvia MostiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Silvia MurachelliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria MussoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Michela NardiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Assunta NavarraNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Emanuele NicastriNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Martina NocioniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Pasquale NotoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Roberto NotoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Alessandra OlivaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Ilaria OnnisNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Sandrine OttouNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Claudia PalazzoloNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Emanuele PalliniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Fabrizio PalmieriNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Giulio PalombiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Carlo PareoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Virgilio PasseriNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Federico PelliccioniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Giovanna PennaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Antonella PetrecchiaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Ada PetroneNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Nicola PetrosilloNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Elisa PianuraNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Carmela PinnettiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria PisciottaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Pierluca PiselliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Silvia PittalisNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Agostina PontarelliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Costanza ProiettiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Vincenzo PuroNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Paolo Migliorisi RamazziniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Alessia RiandaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Gabriele RinonapoliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Silvia RosatiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Dorotea RubinoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Martina RuecaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Alberto RuggeriNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Alessandra SacchiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Alessandro SampaolesiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Francesco SanasiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Carmen SantagataNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Alessandra ScarabelloNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Silvana ScarciaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Vincenzo SchininàNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Paola ScognamiglioNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Laura ScorzoliniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Giulia StaziNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Giacomo StranoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Fabrizio TagliettiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Chiara TaibiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Giorgia TaloniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Tetaj NardiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Roberto TonnariniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Simone TopinoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Martina TozziNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Francesco VaiaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Francesco VairoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria Beatrice ValliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Alessandra VergoriNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Laura VincenziNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Ubaldo Visco-ComandiniNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Serena VitaNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Pietro VittozziNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Mauro ZaccarelliNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Antonella ZanettiNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Sara ZitoNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
INMI Recovery study groupNational Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimited data are available about the predictors and outcomes associated with prolonged SARS-CoV-2 RNA shedding (VS).
methodsA retrospective study including COVID-19 patients admitted to an Italian hospital between March 1 and July 1, 2020. Predictors of viral clearance (VC) and prolonged VS from the upper respiratory tract were assessed by Poisson regression and logistic regression analyses. The causal relation between VS and clinical outcomes was evaluated through an inverse probability weighted Cox model.
resultsThe study included 536 subjects. The median duration of VS from symptoms onset was 18 days. The estimated 30-day probability of VC was 70.2%. Patients with comorbidities, lymphopenia at hospital admission, or moderate/severe respiratory disease had a lower chance of VC. The development of moderate/severe respiratory failure, delayed hospital admission after symptoms onset, baseline comorbidities, or D-dimer >1000ng/mL at admission independently predicted prolonged VS. The achievement of VC doubled the chance of clinical recovery and reduced the probability of death/mechanical ventilation.
conclusionsRespiratory disease severity, comorbidities, delayed hospital admission and inflammatory markers negatively predicted VC, which resulted to be associated with better clinical outcomes. These findings highlight the importance of prompt hospitalization of symptomatic patients, especially where signs of severity or comorbidities are present.
Indexed as
Virus SheddingAdultAgedCohort StudiesCOVID-19FemaleHumansMaleMiddle AgedProportional Hazards ModelsRespiratory SystemRNA, ViralSARS-CoV-2Severity of Illness IndexTime FactorsRNA, ViralCoronavirusCOVID-19, viral clearance, viral sheddingRisk factorsSARS-CoV-2
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