Trial reportThe Journal of allergy and clinical immunology2021
Peanut diversity and specific activity are the dominant IgE characteristics for effector cell activation in children.
Trial report in The Journal of allergy and clinical immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- IgE Antibody Function and Mast Cell Activation to Egg in Children Undergoing Baked and Loosely Cooked Egg Challenges.Allergy · 2026Article
- Review
- Casein sIgE avidity and milk basophil reactivity in children with cow's milk allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Fine resolution of the N-terminal IgE-binding epitope of Ara h 2: Discovery of variants with enhanced IgE binding.The Journal of allergy and clinical immunology · 2025Article
- Allergic Reactivity and Memory Occur Independently of Sequential Switching Through IgG1.Allergy · 2025Article
- Epitope-Specific Antibodies in Allergic Disease and Clinical Tolerance.Immunological reviews · 2025Review
- Aberrant Activation of Mast Cells: Molecular Mechanisms and Targets for Intervention.Clinical reviews in allergy & immunology · 2025Review
- Germline-encoded recognition of peanut underlies development of convergent antibodies in humans.Science translational medicine · 2025Article
- Allergen extract outperforms molecular components in basophil activation test in a pediatric cohort.Frontiers in immunology · 2025Article
- Clinical utility analysis of the Hoxb8 mast cell activation test for the diagnosis of peanut allergy.Allergy · 2025Article
- Biomarkers of peanut allergy in children over time.Allergy · 2024Article
- Whence and wherefore IgE?Immunological reviews · 2024Review
- Prediction of pediatric peanut oral food challenge outcomes using machine learning.The journal of allergy and clinical immunology. Global · 2024Article
- Basophil activation test as predictor of severity and threshold of allergic reactions to egg.Allergy · 2024Article
- The future of food allergy diagnosis.Frontiers in allergy · 2024Review
- Peanut allergen Ara h 6 is detectable in blood transfusion products.Clinical and translational allergy · 2023Article
- Novel, computational IgE-clustering in a population-based cross-sectional study: Mapping the allergy burden.Clinical and translational allergy · 2023Article
- The Very Low IgE Producer: Allergology, Genetics, Immunodeficiencies, and Oncology.Biomedicines · 2023Review
- Will Oral Food Challenges Still Be Part of Allergy Care in 10 Years' Time?The journal of allergy and clinical immunology. In practice · 2023Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundIgE mediates allergic reactions to peanut; however, peanut-specific IgE (sIgE) levels do not always equate to clinical peanut allergy. Qualitative differences between sIgE of peanut-sensitized but tolerant (PS) and peanut-allergic (PA) individuals may be important.
objectiveWe sought to assess the influence of IgE characteristics on effector cell activation in peanut allergy.
methodsA cohort of 100 children was studied. The levels of IgE to peanut and peanut components were measured. Specific activity (SA) was estimated as the ratio of allergen-sIgE to total IgE. Avidity was measured by ImmunoCAP with sodium thiocyanate. IgE diversity was calculated on the basis of ImmunoCAP-Immuno Solid-phase Allergen Chip assays for 112 allergens or for 6 peanut allergens. Whole-blood basophils and mast cell line Laboratory of Allergic Diseases 2 sensitized with patients' plasma were stimulated with peanut or controls and assessed by flow cytometry.
resultsSA to peanut (P < .001), Ara h 1 (P = .004), Ara h 2 (P < .001), Ara h 3 (P = .02), and Ara h 6 (P < .001) and the avidity of peanut-sIgE (P < .001) were higher in PA than in PS individuals. Diversity for peanut allergens was greater in PA individuals (P < .001). All IgE characteristics were correlated with basophil and mast cell activation. Peanut SA (R = 0.447) and peanut diversity (R = 0.440) had the highest standardized β-coefficients in combined multivariable regression models (0.447 and 0.440, respectively).
conclusionsIgE specificity, SA, avidity, and peanut diversity were greater in PA than in PS individuals. IgE peanut SA and peanut diversity had the greatest influence on effector cell activation and could be used clinically.
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