Evidence map›Paper›PMID 33675778›Full record

ReviewExperimental eye research2021

A smartphone based method for mouse fundus imaging.

Michael Peng, Bomina Park, Hemavathy Harikrishnan, Sultana N Jahan, Jiannong Dai, Naga Pradeep Rayana, Chenna Kesavulu Sugali, Tasneem P Sharma, Sanae Imanishi, Yoshikazu Imanishi and 2 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental eye research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Michael PengEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA.
Bomina ParkEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA; Department of Pharmacology and Toxicology, Indiana University School of Medicine, USA.
Hemavathy HarikrishnanEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA.
Sultana N JahanEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA.
Jiannong DaiEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA.
Naga Pradeep RayanaEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA.
Chenna Kesavulu SugaliEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA.
Tasneem P SharmaEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA; Department of Pharmacology and Toxicology, Indiana University School of Medicine, USA.
Sanae ImanishiEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA.
Yoshikazu ImanishiEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA; Department of Pharmacology and Toxicology, Indiana University School of Medicine, USA.
Timothy W CorsonEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA; Department of Pharmacology and Toxicology, Indiana University School of Medicine, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, USA.
Weiming MaoEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, USA. Electronic address: weimmao@iu.edu.
Indiana University School of Medicine

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Ferrochelatase as a mediator of ocular angiogenesisR01EY025641 · NEI · UNIVERSITY OF TORONTO · PI Timothy W Corson · 2016 to 2026
$3.5M
Cross-talk between TGF-beta and Wnt pathways in the trabecular meshworkR01EY026962 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI MAO, WEIMING · 2017 to 2021
$1.9M
Targeting the Ref-1 signaling node for treating ocular neovascularizationR01EY031939 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI CORSON, TIMOTHY W, KELLEY, MARK R. · 2020 to 2023
$1.7M
NCATS NIH HHS UL1 TR002529NEI NIH HHS R01 EY025641NEI NIH HHS R01 EY026962NEI NIH HHS R01 EY031939
6 · The paper itself

Abstract

Noninvasive in vivo imaging of the mouse retina is essential for eye research. However, imaging the mouse fundus is challenging due to its small size and requires specialized equipment, maintenance, and training. These issues hinder the routine evaluation of the mouse retina. In this study, we developed a noncontact imaging system consisting of a smartphone, a 90D condensing lens, a homemade light diaphragm, a tripod, and a Bluetooth remote. With minimal training, examiners were able to capture fundus images from the mouse retina. We also found that fundus images captured using our system from wild type mice, mice with laser-induced retinal injury, and a mouse model of retinitis pigmentosa showed a quality similar to those captured using a commercial fundus camera. These images enabled us to identify normal structures and pathological changes in the mouse retina. Additionally, fluorescein angiography was possible with the smartphone system. We believe that the smartphone imaging system is low cost, simple, accessible, easy to operate, and suitable for the routine screening and examination of the mouse eye.

Indexed as

SmartphoneAnimalsFluorescein AngiographyFundus OculiMiceOphthalmoscopyRetinaRetinal DiseasesFluorescein angiographyFundus imagingLaser-induced retinal injuryMouse retinaRetinitis pigmentosaSmartphone

Identifiers

PMID33675778
PMCPMC8087636
OpenAlexW3134470825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.