ReviewMicrobial biotechnology2022
Carbon catabolite regulation of secondary metabolite formation, an old but not well-established regulatory system.
Review in Microbial biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 48 citations in OpenAlex.
- Antibiotic-producing microorganisms: taxonomic diversity, screening strategies, and emerging and underexploited antibacterial targets.Archives of microbiology · 2026Review
- Secondary Metabolite Biosynthesis and Regulatory Role of Sucrose inMicroorganisms · 2026Review
- Regulatory and metabolic control of microbial biosynthetic gene clusters.Communications biology · 2026Review
- Exploitation of actinomycetes from coastal ecosystems of İzmir Peninsula for antimicrobial activity via strain identification, untargeted metabolomics and drug combination studies.Microbial cell factories · 2026Article
- Phosphorylated lantibiotics-producing commensals integrate into the human oral microbiome to suppress pathogens and promote microbiome homeostasis.NPJ biofilms and microbiomes · 2026Article
- Exploration of yeast biodiversity from Thai flowers and optimization of carotenoid production by a promising isolate.Journal of industrial microbiology & biotechnology · 2026Article
- Impact of the Transcriptional Regulator SCO7424 Overexpression on Antibiotic Production inAntibiotics (Basel, Switzerland) · 2026Article
- Article
- Environmental conditions and ecological interactions among microorganisms isolated from diseased samples shape their biocontrol efficacy againstFrontiers in microbiology · 2026Article
- Microbial Metabolism: Primary and Secondary Metabolites.Progress in molecular and subcellular biology · 2026Review
- Transcriptional analysis of genes associated with glycolysis in Streptomyces coelicolor M145.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Pigment Formation byJournal of agricultural and food chemistry · 2025Article
- Carbon-Source Effects on Growth and Secondary Metabolism in the Marine BacteroidotaMarine drugs · 2025Article
- A Scorecard for Information Synthesis in Multiple Experimental Conditions: Application to Bacterial Biofilm Matrix Transcriptomics.Current microbiology · 2025Article
- Enhancement of Mycelial Growth and Antifungal Activity by Combining Fermentation Optimization and Genetic Engineering inMicroorganisms · 2025Article
- Actinomycetes from high altitude salt lake Tso-Kar of Ladakh offers bright prospects for antimycobacterial drug discovery especially for drug resistant mycobacteria.Extremophiles : life under extreme conditions · 2025Article
- Differential anaerobic oxidation of benzoate inMicrobiology spectrum · 2025Article
- Regulation of Sugar Metabolism During Fermentation of Brewers' Spent Grain by Leuconostoc pseudomesenteroides DSM20193.Microbial biotechnology · 2025Article
- Multiomic Analysis Provided Insights into the Responses of Carbon Sources by Wood-Rotting FungiJournal of fungi (Basel, Switzerland) · 2025Article
- Optimization of fermentation conditions to increase the production of antifungal metabolites from Streptomyces sp. KN37.Microbial cell factories · 2025Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secondary microbial metabolites have various functions for the producer microorganisms, which allow them to interact and survive in adverse environments. In addition to these functions, other biological activities may have clinical relevance, as diverse as antimicrobial, anticancer and hypocholesterolaemic effects. These metabolites are usually formed during the idiophase of growth and have a wide diversity in their chemical structures. Their synthesis is under the impact of the type and concentration of the culture media nutrients. Some of the molecular mechanisms that affect the synthesis of secondary metabolites in bacteria (Gram-positive and negative) and fungi are partially known. Moreover, all microorganisms have their peculiarities in the control mechanisms of carbon sources, even those belonging to the same genus. This regulatory knowledge is necessary to establish culture conditions and manipulation methods for genetic improvement and product fermentation. As the carbon source is one of the essential nutritional factors for antibiotic production, its study has been imperative both at the industrial and research levels. This review aims to draw the utmost recent advances performed to clarify the molecular mechanisms of the negative effect exerted by the carbon source on the secondary metabolite formation, emphasizing those found in Streptomyces, one of the genera most profitable antibiotic producers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.