Evidence map›Paper›PMID 33675470›Full record

ArticleInternational urology and nephrology2021

Clinical features and outcomes of anti-neutrophil cytoplasmic autoantibody-associated vasculitis in Chinese elderly and very elderly patients.

Ting Meng, Yong Zhong, Jinbiao Chen, Ya-Ou Zhou, Xiaoxia Zuo, Hui Luo, Wei Lin, Ting Wu, Yingqiang Yang, Zhou Xiao and 5 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Ting MengDepartment of Nephrology, Xiangya Hospital Central South University, Changsha, 410008, Hunan, People's Republic of China.
Yong ZhongDepartment of Nephrology, Xiangya Hospital Central South University, Changsha, 410008, Hunan, People's Republic of China.
Jinbiao ChenDepartment of Medical Records and Information, Xiangya Hospital Central South University, Changsha, 410008, Hunan, People's Republic of China.
Ya-Ou ZhouDepartment of Rheumatology and Immunology, Xiangya Hospital Central South University, Changsha, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China. zhouyaou@csu.edu.cn.
Xiaoxia ZuoDepartment of Rheumatology and Immunology, Xiangya Hospital Central South University, Changsha, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China.
Hui LuoDepartment of Rheumatology and Immunology, Xiangya Hospital Central South University, Changsha, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China.
Wei LinDepartment of Pathology, Xiangya Hospital Central South University, Changsha, 410008, Hunan, People's Republic of China.
Ting WuDepartment of Nephrology, Xiangya Hospital Central South University, Changsha, 410008, Hunan, People's Republic of China.
Yingqiang YangDepartment of Nephrology, Xiangya Hospital Central South University, Changsha, 410008, Hunan, People's Republic of China.
Zhou XiaoDepartment of Nephrology, Xiangya Hospital Central South University, Changsha, 410008, Hunan, People's Republic of China.
Rong TangDepartment of Nephrology, Xiangya Hospital Central South University, Changsha, 410008, Hunan, People's Republic of China.
Xiang AoDepartment of Nephrology, Xiangya Hospital Central South University, Changsha, 410008, Hunan, People's Republic of China.
Xiangcheng XiaoDepartment of Nephrology, Xiangya Hospital Central South University, Changsha, 410008, Hunan, People's Republic of China.
Qiaoling ZhouDepartment of Nephrology, Xiangya Hospital Central South University, Changsha, 410008, Hunan, People's Republic of China.
Ping XiaoDepartment of Nephrology, Xiangya Hospital Central South University, Changsha, 410008, Hunan, People's Republic of China.
Central South University · CNXiangya Hospital Central South University · CN

Funding

Chinese Society of Nephrology 18020010780National Natural Science Foundation of China 81800641Natural Science Foundation of Hunan Province 2018JJ3818Natural Science Foundation of Hunan Province 2018JJ3853the Project of Health Commission of Hunan province C2019184
6 · The paper itself

Abstract

purposeAnti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV) is predominantly a disease of the elderly, and the incidence increases with age. However, there are few data focusing on the clinical features in elderly onset AAV, especially in very elderly onset AAV in China. The aim of this study was to explore whether elderly onset AAV shows any specific clinical features and outcomes in Chinese patients.

methodsWe performed a retrospective study in Xiangya Hospital, a mixed tertiary medical center in south China. A total of 177 patients presenting with AAV were included between January 1, 2010 and December 31, 2017. Patients were divided into younger group (age < 65 years) and older group (age ≥ 65 years) which was sub-divided into elderly group (age 65-74 years) and very elderly group (age ≥ 75 years). And their medical records were analyzed by retrospective review.

resultsWe found patients in the very elderly group had more chest and cardiovascular involvement (P = 0.033 and P = 0.017). Older AAV patients had less renal involvement and lower serum C4 level (P = 0.013 and P = 0.003). Very elderly AAV patients had lower platelet counts. Patients in the younger group had a higher level of BVAS among three groups (P < 0.05 younger group vs. very elderly group; P < 0.05 younger group vs. elderly group). There were no significant difference in the proportion of ESRD patients among the three groups (P = 0.473). Patients in the very elderly group had the poorest patient survival (P = 0.002).

conclusionOlder AAV patients had less renal involvement, lower serum C4 level and BVAS. The very elderly group got the most chest and cardiovascular involvement and had lower platelet counts. Older age is associated with higher mortality in AAV patients.

Indexed as

AgedAged, 80 and overAge FactorsAge of OnsetAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisChinaFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeAnti-neutrophil cytoplasmic autoantibody-associated vasculitisClinical featuresElderly onsetGlomerulonephritisOutcomes

Identifiers

PMID33675470
OpenAlexW3134037206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.