Evidence map›Paper›PMID 33675370›Full record

ArticleCalcified tissue international2021

Phenanthrenoid Coelogin Isolated from Coelogyne cristata Exerts Osteoprotective Effect Through MAPK-Mitogen-Activated Protein Kinase Signaling Pathway.

Ravi Prakash, Tripti Mishra, Kapil Dev, Kriti Sharma, Jitendra Kuldeep, Aijaz Ahmad John, Alok Tripathi, Chetan Sharma, Kamal Ram Arya, Brijesh Kumar and 3 more

Abstract read
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In one paragraph

Article in Calcified tissue international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Ravi Prakash *Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.
Tripti Mishra *Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.
Kapil Dev *Ethnobotany Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.
Kriti SharmaEndocrinology Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.
Jitendra KuldeepMolecular and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.
Aijaz Ahmad JohnEndocrinology Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.
Alok TripathiEndocrinology Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.
Chetan SharmaEthnobotany Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.
Kamal Ram AryaEthnobotany Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.
Brijesh KumarSophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.
Mohd Imran SiddiqiMolecular and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.
Narender TadigoppulaMedicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India. t_narendra@cdri.res.in.
Divya SinghEndocrinology Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India. divya_singh@cdri.res.in.ORCID 0000-0002-2487-4082
Central Drug Research Institute · IN

Funding

Council of Scientific and Industrial Research BSC0201Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy GAP0171
6 · The paper itself

Abstract

Osteoporosis is a major health problem in postmenopausal women globally. This study determined the mechanism through which coelogin stimulates osteoblastogenesis and its osteoprotective and bone regenerating potential. Coelogin effect on primary calvarial osteoblast cells was determined by measuring alkaline phosphatase activity, mineralization, osteoblast survival, and apoptosis and protein expression studies. The osteoprotective effect of coelogin was also evaluated on osteopenic adult female Swiss mice. At autopsy, bones were collected for dynamic and histomorphometry studies. Serum samples were also collected for assessment of serum parameters. Coelogin treatment led to increased osteoblast proliferation, survival, differentiation, and mineralization in osteoblast cells. Coelogin supplementation to Ovx mice promoted new bone formation, prevented Ovx-induced deterioration of bone microarchitecture, and enhanced bone regeneration. In addition, signaling studies revealed that coelogin treatment activates the ER-Erk and Akt-dependent signaling pathways which stimulate the osteoblastogenesis in osteoblast cells.

Indexed as

Mitogen-Activated Protein KinasesOsteoblastsAnimalsCell DifferentiationFemaleHumansMiceOsteogenesisOvariectomyPhenanthrenesPyransSignal Transduction7,8-dimethoxy-9,10-dihydro-5H-naphtho(8,1,2-cde)chromene-2,6-diolMitogen-Activated Protein KinasesPhenanthrenesPyrans

Identifiers

PMID33675370
OpenAlexW3135022519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.