Evidence map›Paper›PMID 33675126›Full record

ArticleNeuropsychopharmacology reports2021

Dietary magnesium deficiency induces the expression of neuroinflammation-related genes in mouse brain.

Ryuhei Tsuji, Hirofumi Inoue, Mariko Uehara, Satoshi Kida

Open access · goldAbstract read
In one paragraph

Article in Neuropsychopharmacology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Magnesium (MgCurrent pharmaceutical design · 2024
    Review
  7. Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration.International journal of molecular sciences · 2022
    Review
  8. Acidosis, cognitive dysfunction and motor impairments in patients with kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ryuhei TsujiDepartment of Applied Biological Chemistry, Graduate school of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan.
Hirofumi InoueFaculty of Applied Bioscience, Department of Nutritional Science and Food Safety, Tokyo University of Agriculture, Tokyo, Japan.
Mariko UeharaFaculty of Applied Bioscience, Department of Nutritional Science and Food Safety, Tokyo University of Agriculture, Tokyo, Japan.
Satoshi KidaDepartment of Applied Biological Chemistry, Graduate school of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-8038-9583
Tokyo University of Agriculture · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsDietary Mg

methodsWe performed RNA-sequencing of the hippocampal transcriptome of MgD mice. We used gene ontology analyses and quantitative real-time PCR to validate the RNA-sequencing results.

resultsmRNAs for neuroinflammation-related genes were upregulated in the hippocampus and cortex of MgD mice.

conclusionMgD induces neuroinflammation in the mouse brain, including the hippocampus and cortex. Our findings suggest that MgD-induced neuroinflammation triggers the impairments of hippocampus-dependent memory.

Indexed as

Magnesium DeficiencyAnimalsHippocampusMemory DisordersMiceMice, Inbred C57BLNeuroinflammatory Diseaseshippocampus-dependent memorymagnesium deficiencymicroglianeuroinflammationtranscriptome

Identifiers

PMID33675126
PMCPMC8340841
OpenAlexW3135238702

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.