Evidence map›Paper›PMID 33674784›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2021

GestAltNet: aggregation and attention to improve deep learning of gestational age from placental whole-slide images.

Pooya Mobadersany, Lee A D Cooper, Jeffery A Goldstein

Open access · bronzeAbstract read
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

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  12. Tissue Contamination Challenges the Credibility of Machine Learning Models in Real World Digital Pathology.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2024
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  14. Enhancing Automatic Placenta Analysis through Distributional Feature Recomposition in Vision-Language Contrastive Learning.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2023
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  19. Training of Deep Learning Pipelines on Memory-Constrained GPUs via Segmented Fused-Tiled Execution.Compiler construction : ... International Conference, CC ... : proceedings. CC (Conference) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pooya MobadersanyDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-9310-1983
Lee A D CooperDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-3504-4965
Jeffery A GoldsteinDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. ja.goldstein@northwestern.edu.ORCID 0000-0002-4086-057X
Northwestern University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Advanced Development of an Open-source Platform for Web-based Integrative Digital Image Analysis in CancerU24CA194362 · NCI · EMORY UNIVERSITY · PI COOPER, LEE, GUTMAN, DAVID ANDREW · 2015 to 2019
$3.6M
Informatics Tools for Quantitative Digital Pathology Profiling and Integrated Prognostic ModelingU01CA220401 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI COOPER, LEE, FLOWERS, CHRISTOPHER R · 2018 to 2021
$1.3M
Developing a virtual placenta biobankK08EB030120 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOLDSTEIN, JEFFERY A · 2020 to 2023
$575k
NCATS NIH HHS UL1 TR001422NCI NIH HHS P30 CA060553NCI NIH HHS U01 CA220401NCI NIH HHS U24 CA194362NIBIB NIH HHS K08 EB030120
6 · The paper itself

Abstract

The placenta is the first organ to form and performs the functions of the lung, gut, kidney, and endocrine systems. Abnormalities in the placenta cause or reflect most abnormalities in gestation and can have life-long consequences for the mother and infant. Placental villi undergo a complex but reproducible sequence of maturation across the third-trimester. Abnormalities of villous maturation are a feature of gestational diabetes and preeclampsia, among others, but there is significant interobserver variability in their diagnosis. Machine learning has emerged as a powerful tool for research in pathology. To capture the volume of data and manage heterogeneity within the placenta, we developed GestaltNet, which emulates human attention to high-yield areas and aggregation across regions. We used this network to estimate the gestational age (GA) of scanned placental slides and compared it to a baseline model lacking the attention and aggregation functions. In the test set, GestaltNet showed a higher r

Indexed as

Deep LearningGestational AgeDiabetes, GestationalFemaleHistocytochemistryHumansImage Interpretation, Computer-AssistedPlacentaPre-EclampsiaPregnancy

Identifiers

PMID33674784
PMCPMC7933605
OpenAlexW3133796368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.