Evidence map›Paper›PMID 33674761›Full record

ArticleMucosal immunology2021

Plectin ensures intestinal epithelial integrity and protects colon against colitis.

Alzbeta Krausova, Petra Buresova, Lenka Sarnova, Gizem Oyman-Eyrilmez, Jozef Skarda, Pavel Wohl, Lukas Bajer, Eva Sticova, Lenka Bartonova, Jiri Pacha and 14 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Mucosal immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Loss of ERβ in Aging LXRαβ Knockout Mice Leads to Colitis.International journal of molecular sciences · 2023
    Article
  9. Polysaccharides fromInternational journal of molecular sciences · 2023
    Article
  10. Activation of P2Y1R impedes intestinal mucosa repair during colitis.International journal of biological sciences · 2023
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 9 institutions in 3 countries.

Alzbeta Krausova *Laboratory of Integrative Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Petra Buresova *Laboratory of Integrative Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Lenka SarnovaLaboratory of Integrative Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Gizem Oyman-EyrilmezLaboratory of Integrative Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Jozef SkardaDepartment of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital in Olomouc, Olomouc, Czech Republic.
Pavel WohlDepartment of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Lukas BajerDepartment of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Eva SticovaDepartment of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Lenka BartonovaDepartment of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Jiri PachaDepartment of Epithelial Physiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Gizela KoubkovaCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Jan ProchazkaCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Marina SpörrerDepartment of Physics, University of Erlangen-Nuremberg, Erlangen, Germany.
Christopher DürrbeckDepartment of Physics, University of Erlangen-Nuremberg, Erlangen, Germany.
Zuzana StehlikovaLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.
Martin VitUniversity of Liberec, Faculty of Mechatronics Informatics and Interdisciplinary Studies, Liberec, Czech Republic.
Natalia ZiolkowskaInstitute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Radislav SedlacekCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Daniel JirakTechnical University of Liberec, Faculty of Health Studie, Liberec, Czech Republic.
Miloslav KverkaLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.
Gerhard WicheDepartment of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.
Ben FabryDepartment of Physics, University of Erlangen-Nuremberg, Erlangen, Germany.
Vladimir KorinekLaboratory of Cell and Developmental Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Martin GregorLaboratory of Integrative Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic. martin.gregor@img.cas.cz.
Czech Academy of Sciences, Institute of Molecular Genetics · CZInstitute of Clinical and Experimental Medicine · CZFriedrich-Alexander-Universität Erlangen-Nürnberg · DECharles University · CZCzech Academy of Sciences · CZCzech Academy of Sciences, Institute of Microbiology · CZTechnical University of Liberec · CZUniversity Hospital Olomouc · CZUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plectin, a highly versatile cytolinker protein, provides tissues with mechanical stability through the integration of intermediate filaments (IFs) with cell junctions. Here, we hypothesize that plectin-controlled cytoarchitecture is a critical determinant of the intestinal barrier function and homeostasis. Mice lacking plectin in an intestinal epithelial cell (IEC; Ple

Indexed as

AdultAgedAnimalsColitisColitis, UlcerativeColonDesmosomesDisease Models, AnimalFemaleHumansIntestinal MucosaKeratinsMaleMiceMice, KnockoutMiddle AgedKeratinsPlectin

Identifiers

PMID33674761
PMCPMC8076044
OpenAlexW3134722313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.