ArticleJournal of perinatology : official journal of the California Perinatal Association2021
Spontaneous intestinal perforation in premature infants: a national study.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Enteral feeding during cyclooxygenase inhibitor treatment for patent ductus arteriosus: A systematic review.Pediatrics international : official journal of the Japan Pediatric SocietyPooled it
- When It Is Not NEC: Recognizing Mimics of Necrotizing Enterocolitis in Preterm Infants.Children (Basel, Switzerland) · 2026Review
- Peritoneal drainage in spontaneous intestinal perforation: a 20-year single center review.Pediatric surgery international · 2026Article
- Doppler abnormality predisposes preterm infants with fetal growth restriction to postnatal intestinal disorder.The journal of obstetrics and gynaecology research · 2025Article
- Bedside Utilization of Intestinal Pathology in Preterm Infants with Surgical Necrotizing Enterocolitis.American journal of perinatology · 2025Review
- Comparative outcomes of spontaneous intestinal perforation and necrotising enterocolitis in preterm infants: a retrospective cohort study from Saudi Arabia.BMJ paediatrics open · 2025Article
- Necrotizing enterocolitis following spontaneous intestinal perforation in very low birth weight neonates.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Retrospective bi-centric observational study comparing primary anastomosis or suturing vs enterostomy for spontaneous intestinal perforations in extremely preterm infants.European journal of pediatrics · 2025Observational
- The Association Between Perinatal Pharmacologic Treatments and Spontaneous Intestinal Perforation in Extremely Preterm Infants: A Propensity Score Matching Study.Children (Basel, Switzerland) · 2025Article
- Initial surgery for spontaneous intestinal perforation in extremely low birth weight infants is not associated with mortality or in-hospital morbidities.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Wide use of broad-spectrum antibiotics in very low birth weight infants with spontaneous focal intestinal perforation-is it really justified?Infection · 2024Article
- Surgery for intestinal injuries in very preterm infants: a Norwegian population-based study with a new approach to disease classification.BMJ paediatrics open · 2024Article
- Spontaneous intestinal perforation among very preterm infants in China: a multicenter cohort study.Translational pediatrics · 2024Article
- Identifying Preoperative Clinical Characteristics of Unexpected Gastrointestinal Perforation in Infants-A Retrospective Cohort Study.Children (Basel, Switzerland) · 2024Article
- Comparison of preoperative and intraoperative surgeon diagnosis and pathologic findings in spontaneous intestinal perforation vs necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Outcomes by disease onset, sex, and intervention in neonates with SIP and surgical NEC.Pediatric research · 2024Article
- Risk factors and epidemiology of spontaneous intestinal perforation among infants born at 22-24 weeks' gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2024Observational
- Postoperative Outcomes, and Growth and Brain Injury Outcomes in Spontaneous Intestinal Perforation vs Surgical Necrotizing Enterocolitis in Preterm Infants.Indian pediatrics · 2023Article
- An Early Presentation of Spontaneous Intestinal Perforation in a Very Low Birth Weight Neonate: A Case Report.Cureus · 2023Article
- Blood Glucose, Lactate and Platelet Count in Infants with Spontaneous Intestinal Perforation versus Necrotizing Enterocolitis-A Pilot Study.Children (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the prevalence and outcomes of spontaneous intestinal perforation (SIP) in very low birth weight infants. STUDY
designThis cross-sectional study utilized the National Inpatient Sample dataset for the years 2002-2017. All premature infants with birth weight (BW) <1500 g and with gestational age (GA) ≤32 weeks were included. Analyses were repeated after stratifying the population into two BW sub-categories <1000 g and 1000-1499 g. Trend analysis was done using Cochran-Armitage test. Regression analysis was conducted to control for gestational age, race, and sex.
resultA total of 658,001 infants were included. SIP (n = 10,443, 1.6%) was mostly (81.9%) in the category <1000 g with 89.9% ≤28 weeks of gestation. There was a significant trend for increased SIP over the years (p < 0.001). SIP was associated with increased mortality (aOR = 2.24, CI: 2.04-2.46, p < 0.001).
conclusionAfter controlling for gestational age and other confounders, SIP is associated with increased mortality in premature infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.