Evidence map›Paper›PMID 33674699›Full record

ArticleScientific reports2021

In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP).

Merricka C Livingstone, Alexis A Bitzer, Alish Giri, Kun Luo, Rajeshwer S Sankhala, Misook Choe, Xiaoyan Zou, S Moses Dennison, Yuanzhang Li, William Washington and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
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  6. Malaria vaccines: a new era of prevention and control.Nature reviews. Microbiology · 2024
    Review
  7. Article
  8. Review
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  12. Article
  13. Article
  14. Article
  15. Review
  16. A multivalentBioengineering & translational medicine · 2023
    Article
  17. Article
  18. Current approaches to malaria vaccines.Current opinion in microbiology · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Merricka C LivingstoneStructural Vaccinology Lab, Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Alexis A BitzerStructural Vaccinology Lab, Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Alish GiriStructural Vaccinology Lab, Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Kun LuoStructural Vaccinology Lab, Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Rajeshwer S SankhalaUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Misook ChoeUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Xiaoyan ZouMalaria Department, Naval Medical Research Center, Silver Spring, MD, USA.
S Moses DennisonCenter for Human Systems Immunology, Duke University Medical Center, Durham, NC, USA.
Yuanzhang LiStatistics and Epidemiology Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
William WashingtonStatistics and Epidemiology Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Viseth NgauyMalaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Georgia D TomarasCenter for Human Systems Immunology, Duke University Medical Center, Durham, NC, USA.
M Gordon JoyceUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Adrian H BatchelorStructural Vaccinology Lab, Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Sheetij DuttaStructural Vaccinology Lab, Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA. sheetij.dutta.civ@mail.mil.
Walter Reed Army Institute of Research · USDuke Medical Center · USHenry M. Jackson Foundation · USNaval Medical Research Command · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasmodium falciparum malaria contributes to a significant global disease burden. Circumsporozoite protein (CSP), the most abundant sporozoite stage antigen, is a prime vaccine candidate. Inhibitory monoclonal antibodies (mAbs) against CSP map to either a short junctional sequence or the central (NPNA)

Indexed as

AnimalsAntibodies, MonoclonalAntibodies, ProtozoanCell LineFemaleHepatocytesHumansMalaria, FalciparumMalaria VaccinesMiceMice, Inbred C57BLPrimary Cell CultureProtozoan ProteinsSporozoitesAntibodies, MonoclonalAntibodies, ProtozoanMalaria VaccinesProtozoan Proteins

Identifiers

PMID33674699
PMCPMC7970865
OpenAlexW3134240677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.