ArticleScientific reports2021
Synthesis and design of Ag-Fe bimetallic nanoparticles as antimicrobial synergistic combination therapies against clinically relevant pathogens.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Effective bio-activities of the metal nanoparticles mycosynthesized by the plants' fungal endophytes.Microbial cell factories · 2026Review
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- Antibiofilm Substantivity of AgNPs in Clinical Oral Biofilms from Patients with Motor and Intellectual Disabilities: An In Vitro and Exploratory Study.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Antibacterial and wound healing activities of AgNPs, ZnONPs, and FeBMC research notes · 2026Article
- Synergistic antimicrobial and antibiofilm effects of mycosynthesized MnO-MgO bimetallic nanoparticles against drug-resistant pathogens.BMC microbiology · 2026Article
- Plant-derived N, S-Co-doped carbon dots enable reductive engineering of Ag-Fe bimetallic nanocomposites with broad-spectrum bioactivity.BMC plant biology · 2026Article
- Ratio-tuned green-synthesized Ag-Fe bimetallic nanoparticles embedded in electrospun gelatin/chitosan nanofibrous scaffolds for antibacterial applications.RSC advances · 2026Article
- Advanced strategies for enhanced decolorization and detoxification of textile dyes using biofilm NASScientific reports · 2026Article
- Highly efficient photocatalytic degradation of dyes and anticancer activity of eco-friendly synthesized Ag/AgRSC advances · 2026Article
- Bimetallic nanocomposite produced from Acacia tortilis subsp. raddiana for the mitigation fungal pathogens in tomatoes.Scientific reports · 2025Article
- Eco-benign phytochemically-functionalized Ag-core Fe-shell bimetallic nanoparticles for targeted antioxidant and anti-inflammatory drug delivery.BMC chemistry · 2025Article
- A novel green biosynthesis approach and structural characterization of Ag-Fe bimetallic nanoparticles using the red alga Galaxaura rugosa.Scientific reports · 2025Article
- A novel green biosynthesis approach and structural characterization of Ag-Fe bimetallic nanoparticles using the red alga Galaxaura rugosa.Scientific reports · 2025Article
- Iron oxide/silver-doped iron oxide nanoparticles: facile synthesis, characterization, antibacterial activity, genotoxicity and anticancer evaluation.Scientific reports · 2025Article
- Review
- Magnetization and superparamagnetic behavior of FeCu nanoalloys at room temperature via synthesis and simulation.Scientific reports · 2025Article
- Exploring the anticancer potential of green synthesized Zn/Cu nanocomposites from olive leaves against lung cancer.Hereditas · 2025Article
- CLINICALLY RELEVANT METALLIC NANOPARTICLES IN TUBERCULOSIS DIAGNOSIS AND THERAPY.Advanced therapeutics · 2025Article
- Review
- Green synthesis of Ag-Fe bimetallic nanoparticles using fungal filtrates: unlocking multifunctional medical and environmental applications.RSC advances · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inappropriate use of antibiotics and the inadequate control of infections have led to the emergence of drug-resistant strains. In recent years, metallo-pharmaceutics and metallic nanoparticles have been proposed as potential alternative antimicrobials due to their broad-spectrum antimicrobial properties. Moreover, recent findings have shown that combinations of transition metal compounds can exhibit synergistic antimicrobial properties. Therefore, the synthesis and design of bimetallic nanoparticles is a field worth exploring to harness the interactions between groups of metals and organic complex structures found in different microbial targets, towards the development of more efficient combinatorial antimicrobials composed of synergistic metals. In this study, we present a green synthesis of Ag-Fe bimetallic nanoparticles using an aqueous extract from the leaves of Gardenia jasminoides. The characterization of the nanoparticles demonstrated that the synthesis methodology produces homogenously distributed core-shell Ag-Fe structures with spherical shapes and average diameter sizes of 13 nm (± 6.3 nm). The Ag-Fe bimetallic nanoparticles showed magnetic and antimicrobial properties; the latter were evaluated against six different, clinically relevant multi-drug-resistant microbial strains. The Ag-Fe bimetallic nanoparticles exhibited an antimicrobial (bactericidal) synergistic effect between the two metals composing the bimetallic nanoparticles compared to the effects of the mono-metallic nanoparticles against yeast and both Gram-positive and Gram-negative multidrug-resistant bacteria. Our results provide insight towards the design of bimetallic nanoparticles, synthesized through green chemistry methodologies, to develop synergistic combinatorial antimicrobials with possible applications in both industrial processes and the treatment of infections caused by clinically relevant drug-resistant strains.
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