Trial reportScientific reports2021
A randomized controlled trial on the effects induced by robot-assisted and usual-care rehabilitation on upper limb muscle synergies in post-stroke subjects.
Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03530358 (MOdularity for SEnsory Motor Control), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MOdularity for SEnsory Motor Control: Implications of Muscle Synergies in Motor Recovery After Stroke
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Effects of robotic-assisted upper extremity therapy for stroke patients in different recovery phases: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Extending reach: hybrid robotic-functional electrical stimulation training for post-stroke upper extremity rehabilitation.Journal of neuroengineering and rehabilitation · 2026Trial
- Surface-Electromyography-Based Co-Contraction Index for Monitoring Upper Limb Improvements in Post-Stroke Rehabilitation: A Pilot Randomized Controlled Trial Secondary Analysis.Sensors (Basel, Switzerland) · 2023Trial
- Validation of a Multimodal Wearable Device Integrating EMG and IMU Sensors for Monitoring Upper Limb Function During Tooth Brushing Activities of Daily Living.Sensors (Basel, Switzerland) · 2026Article
- EMG-guided human-machine interaction training develops new intermuscular coordination patterns in stroke: a pilot study.Journal of neuroengineering and rehabilitation · 2025Article
- A Kinematic and EMG Dataset for Upper Limb and Hand Movement Analysis in Post-Stroke and Healthy Subjects.Scientific data · 2025Article
- Electromyographic and Kinematic Analysis of the Upper Limb During Drinking and Eating Using a Wearable Device Prototype.Sensors (Basel, Switzerland) · 2025Article
- An EEG-EMG dataset from a standardized reaching task for biomarker research in upper limb assessment.Scientific data · 2025Article
- Muscle synergies in upper limb stroke rehabilitation: a scoping review.European journal of physical and rehabilitation medicine · 2024Article
- Investigation of adaptive muscle synergy modulated motor responses to grasping perturbations.Scientific reports · 2024Article
- Effect of concurrent action observation, peripheral nerve stimulation and motor imagery on dexterity in patients after stroke: a pilot study.Scientific reports · 2024Article
- Transferring Sensor-Based Assessments to Clinical Practice: The Case of Muscle Synergies.Sensors (Basel, Switzerland) · 2024Article
- Therapeutic robots for post-stroke rehabilitation.Medical review (2021) · 2024Review
- The impact of reminiscent music therapy and robot-assisted rehabilitation on older stroke patients: a protocol for a randomized controlled trial.Frontiers in neurology · 2024Article
- Muscle synergies for evaluating upper limb in clinical applications: A systematic review.Heliyon · 2023Review
- Effects of Upper Limb Robot-Assisted Rehabilitation Compared with Conventional Therapy in Patients with Stroke: Preliminary Results on a Daily Task Assessed Using Motion Analysis.Sensors (Basel, Switzerland) · 2023Article
- A unified scheme for the benchmarking of upper limb functions in neurological disorders.Journal of neuroengineering and rehabilitation · 2022Article
- Biomechanical assessment of the ipsilesional upper limb in post-stroke patients during multi-joint reaching tasks: A quantitative study.Frontiers in rehabilitation sciences · 2022Article
- The effects of robotic assistance on upper limb spatial muscle synergies in healthy people during planar upper-limb training.PloS one · 2022Article
- Muscle Synergies and Clinical Outcome Measures Describe Different Factors of Upper Limb Motor Function in Stroke Survivors Undergoing Rehabilitation in a Virtual Reality Environment.Sensors (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscle synergies are hypothesized to reflect connections among motoneurons in the spinal cord activated by central commands and sensory feedback. Robotic rehabilitation of upper limb in post-stroke subjects has shown promising results in terms of improvement of arm function and motor control achieved by reassembling muscle synergies into a set more similar to that of healthy people. However, in stroke survivors the potentially neurophysiological changes induced by robot-mediated learning versus usual care have not yet been investigated. We quantified upper limb motor deficits and the changes induced by rehabilitation in 32 post-stroke subjects through the movement analysis of two virtual untrained tasks of object placing and pronation. The sample analyzed in this study is part of a larger bi-center study and included all subjects who underwent kinematic analysis and were randomized into robot and usual care groups. Post-stroke subjects who followed robotic rehabilitation showed larger improvements in axial-to-proximal muscle synergies with respect to those who underwent usual care. This was associated to a significant improvement of the proximal kinematics. Both treatments had negative effects in muscle synergies controlling the distal district. This study supports the definition of new rehabilitative treatments for improving the neurophysiological recovery after stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.