Evidence map›Paper›PMID 33674653›Full record

ArticleScientific reports2021

A centrifugal microfluidic cross-flow filtration platform to separate serum from whole blood for the detection of amphiphilic biomarkers.

Kiersten D Lenz, Shailja Jakhar, Jing W Chen, Aaron S Anderson, Dylan C Purcell, Mohammad O Ishak, Jennifer F Harris, Leyla E Akhadov, Jessica Z Kubicek-Sutherland, Pulak Nath and 1 more

Abstract read
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In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Microfluidic pumps for cell sorting.Biomicrofluidics · 2023
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kiersten D LenzPhysical Chemistry and Applied Spectroscopy, Los Alamos National Laboratory, Los Alamos, NM, USA.
Shailja Jakhar *Physical Chemistry and Applied Spectroscopy, Los Alamos National Laboratory, Los Alamos, NM, USA.
Jing W Chen *Applied Modern Physics, Los Alamos National Laboratory, Los Alamos, NM, USA.
Aaron S AndersonPhysical Chemistry and Applied Spectroscopy, Los Alamos National Laboratory, Los Alamos, NM, USA.
Dylan C PurcellApplied Modern Physics, Los Alamos National Laboratory, Los Alamos, NM, USA.
Mohammad O IshakBiosecurity and Public Health, Los Alamos National Laboratory, Los Alamos, NM, USA.
Jennifer F HarrisBiosecurity and Public Health, Los Alamos National Laboratory, Los Alamos, NM, USA.
Leyla E AkhadovBiosecurity and Public Health, Los Alamos National Laboratory, Los Alamos, NM, USA.
Jessica Z Kubicek-SutherlandPhysical Chemistry and Applied Spectroscopy, Los Alamos National Laboratory, Los Alamos, NM, USA.
Pulak NathApplied Modern Physics, Los Alamos National Laboratory, Los Alamos, NM, USA. pulakn.lanl@gmail.com.
Harshini MukundanPhysical Chemistry and Applied Spectroscopy, Los Alamos National Laboratory, Los Alamos, NM, USA. harshini@lanl.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The separation of biomarkers from blood is straightforward in most molecular biology laboratories. However, separation in resource-limited settings, allowing for the successful removal of biomarkers for diagnostic applications, is not always possible. The situation is further complicated by the need to separate hydrophobic signatures such as lipids from blood. Herein, we present a microfluidic device capable of centrifugal separation of serum from blood at the point of need with a system that is compatible with biomarkers that are both hydrophilic and hydrophobic. The cross-flow filtration device separates serum from blood as efficiently as traditional methods and retains amphiphilic biomarkers in serum for detection.

Indexed as

Lab-On-A-Chip DevicesAnimalsBiomarkersBlood Cell CountCell SeparationMicrofluidic Analytical TechniquesSerumSheepSurface-Active AgentsBiomarkersSurface-Active Agents

Identifiers

PMID33674653
PMCPMC7935985

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.