Evidence map›Paper›PMID 33674185›Full record

ReviewCytokine & growth factor reviews2021

SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders.

Narayanappa Amruta, Wesley H Chastain, Meshi Paz, Rebecca J Solch, Isabel C Murray-Brown, Jaime B Befeler, Timothy E Gressett, Michele T Longo, Elizabeth B Engler-Chiurazzi, Gregory Bix

Open access · greenAbstract readReview
In one paragraph

Review in Cytokine & growth factor reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.

  1. Pooled it
  2. Review
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  7. Epidemiology of Parkinson's Disease: An Update.Current neurology and neuroscience reports · 2024
    Review
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  10. Observational
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Narayanappa AmrutaDepartment of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Wesley H ChastainDepartment of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Meshi PazDepartment of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Rebecca J SolchDepartment of Neurology, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Isabel C Murray-BrownDepartment of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Jaime B BefelerDepartment of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Timothy E GressettDepartment of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Michele T LongoDepartment of Neurology, Tulane University School of Medicine, New Orleans, LA, 70112, USA; Tulane Brain Institute, Tulane University, New Orleans, LA, 70112, USA.
Elizabeth B Engler-ChiurazziDepartment of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA; Tulane Brain Institute, Tulane University, New Orleans, LA, 70112, USA.
Gregory BixDepartment of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA; Department of Neurology, Tulane University School of Medicine, New Orleans, LA, 70112, USA; Tulane Brain Institute, Tulane University, New Orleans, LA, 70112, USA. Electronic address: gbix@tulane.edu.
Tulane University · US

Funding

Perlecan Domain V is a Novel Promoter of Brain Repair after StrokeR01NS065842 · NINDS · UNIVERSITY OF KENTUCKY · PI BIX, GREGORY JAYE · 2010 to 2019
$3.2M
The Role of Perlecan Domain V in Vascular DementiaR01NS089515 · NINDS · UNIVERSITY OF KENTUCKY · PI BIX, GREGORY JAYE · 2014 to 2018
$1.6M
Assessment of Mechanisms Underlying B Cell Impacts on Resilience and Susceptibility to StressK01MH117343 · NIMH · WEST VIRGINIA UNIVERSITY · PI ENGLER-CHIURAZZI, ELIZABETH · 2020 to 2023
$576k
NIMH NIH HHS K01 MH117343NINDS NIH HHS R01 NS065842NINDS NIH HHS R01 NS089515
6 · The paper itself

Abstract

SARS-CoV-2 is a novel coronavirus that severely affects the respiratory system, is the cause of the COVID-19 pandemic, and is projected to result in the deaths of 2 million people worldwide. Recent reports suggest that SARS-CoV-2 also affects the central nervous system along with other organs. COVID-19-associated complications are observed in older people with underlying neurological conditions like stroke, Alzheimer's disease, and Parkinson's disease. Hence, we discuss SARS-CoV-2 viral replication and its inflammation-mediated infection. This review also focuses on COVID-19 associated neurological complications in individuals with those complications as well as other groups of people. Finally, we also briefly discuss the current therapies available to treat patients, as well as ongoing available treatments and vaccines for effective cures with a special focus on the therapeutic potential of a small 5 amino acid peptide (PHSCN), ATN-161, that inhibits SARS-CoV-2 spike protein binding to both integrin α5β1 and α5β1/hACE2.

Indexed as

AgedAged, 80 and overAge FactorsCOVID-19HumansNervous System DiseasesNeurogenic InflammationNeuroimmunomodulationPandemicsSARS-CoV-2COVID-19FibrosisIntegrinsNeuroinflammationNeurological disordersSARS-CoV-2

Identifiers

PMID33674185
PMCPMC7894219
OpenAlexW3130518159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.