Evidence map›Paper›PMID 33674151›Full record

ReviewTrends in biochemical sciences2021

Direct Structural Insights into GABA

Jeong Joo Kim, Ryan E Hibbs

Open access · greenAbstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. GABACellular and molecular neurobiology · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Excavating Precursors from the Traditional Chinese Pair HerbsPharmaceuticals (Basel, Switzerland) · 2026
    Article
  9. Article
  10. Article
  11. Targeting the intestinal TLR4-GABAJournal of neuroinflammation · 2026
    Article
  12. Article
  13. Article
  14. Direct modulation of human GABA-A αFrontiers in neuroscience · 2026
    Review
  15. βInternational journal of molecular sciences · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Φ value analysis underscores strong functional and structural compactness of the GABAProceedings of the National Academy of Sciences of the United States of America · 2025
    Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jeong Joo KimDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Ryan E HibbsDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: ryan.hibbs@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · US

Funding

Structure and Function of GABA-A ReceptorsR01DA047325 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI Ryan E Hibbs, David W Nauen · 2019 to 2026
$4.4M
Structural basis of nicotinic acetylcholine receptor gating and toxin inhibitionR01NS120496 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI HIBBS, RYAN E · 2021 to 2025
$3.3M
Structural studies of heteromeric nicotinic acetylcholine receptors - Diversity SupplementR01DA042072 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI HIBBS, RYAN E · 2016 to 2020
$2.0M
3D Structure and mechanism of the alpha7 nicotinic acetylcholine receptorR01NS095899 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI HIBBS, RYAN E · 2016 to 2020
$1.8M
Structural biology of the alpha4beta2 nicotinic acetylcholine receptorR33DA037492 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI HIBBS, RYAN E · 2017 to 2018
$802k
Structural biology of the alpha4beta2 nicotinic acetylcholine receptorR21DA037492 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI HIBBS, RYAN E · 2014 to 2015
$368k
NIDA NIH HHS R01 DA042072NIDA NIH HHS R01 DA047325NIDA NIH HHS R21 DA037492NIDA NIH HHS R33 DA037492NINDS NIH HHS R01 NS095899NINDS NIH HHS R01 NS120496
6 · The paper itself

Abstract

GABA

Indexed as

Ligand-Gated Ion ChannelsReceptors, GABA-ALigand-Gated Ion ChannelsReceptors, GABA-Abenzodiazepinebicucullinecryo-EM structureCys-loop receptor structuregeneral anestheticpicrotoxin

Identifiers

PMID33674151
PMCPMC8122054
OpenAlexW3135743555

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.