Evidence map›Paper›PMID 33673871›Full record

ArticleBMC chemistry2021

Experimental and computational studies of an antiplasmodial derivative of allantoin; antimycobacterial essential oil from Cordia batesii WERNHAM (Boraginaceae).

Eric Robert Tiam, Dominique Serge Ngono Bikobo, Ibrahim Mbouombouo Ndassa, Norbert Mbabi Nyemeck Ii, Auguste Abouem A Zintchem, Lawrence Ayong, Patrick Hervé Betote Diboué, Bruno Lenta Ndjakou, Joséphine Ngo Mbing, Dieudonné Emmanuel Pegnyemb

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In one paragraph

Article in BMC chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eric Robert TiamDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O Box 812, Yaounde, Cameroon.
Dominique Serge Ngono BikoboDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O Box 812, Yaounde, Cameroon.
Ibrahim Mbouombouo NdassaDepartment of Inorganic Chemistry, Faculty of Science, University of Yaoundé I, P.O Box 812, Yaounde, Cameroon.
Norbert Mbabi Nyemeck IiDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O Box 812, Yaounde, Cameroon.
Auguste Abouem A ZintchemDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O Box 812, Yaounde, Cameroon. augabouem@yahoo.fr.
Lawrence AyongCentre Pasteur du Cameroun, Yaounde, Cameroon.
Patrick Hervé Betote DibouéCentre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaounde, Cameroon.
Bruno Lenta NdjakouDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O Box 812, Yaounde, Cameroon.
Joséphine Ngo Mbing *Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O Box 812, Yaounde, Cameroon.
Dieudonné Emmanuel Pegnyemb *Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O Box 812, Yaounde, Cameroon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChemical and pharmacological investigations were performed on the stems of Cordia batesii (Boraginaeae); chemical studies included quantum calculations applied on a newly described compound.

resultsA new derivative of allantoin (1) named batesiin (2) was characterized. Thirteen other known compounds involving allantoin (1) were either isolated or identified. GC-MS enabled the identification of six compounds from a fraction containing essential oil. MeOH extract and some isolated compounds were tested in vitro against Pf7G8 CQS and Pf Dd2 CQR strains of Plasmodium falciparum; extract disclosed a moderate antiplasmodial activity (IC

conclusionCordia batesii can be considered as promising in search of compounds with antimalarial and antitubercular properties. DFT studies are very helpful when trying to learn more about the spectroscopic insights of a derivative of allantoin (1).

Indexed as

AllantoinBatesiinCordia batesiiDFTEssential oilMolecular orbitalsMycobacterium tuberculosisPlasmodium falciparumSpectroscopy

Identifiers

PMID33673871
PMCPMC7934435

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.