ArticleBiomedicines2021
Obesity Affects HDL Metabolism, Composition and Subclass Distribution.
Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 77 citations in OpenAlex.
- Trial
- Trial
- Dietary ω3 Fatty Acids and Phytosterols in the Modulation of the HDL Lipidome: A Longitudinal Crossover Clinical Study.Nutrients · 2023Trial
- Early Emergence of HDL Oxidation Across the Body Mass Index Spectrum in Patients with Suspected Coronary Artery Disease.International journal of molecular sciences · 2026Article
- Safety and Efficacy Assessment of Cannabis Plant Compared to Atorvastatin for Lipid Lowering in Diabetic and Obese Wistar Male Rats.Life (Basel, Switzerland) · 2026Article
- Metabolically healthy obesity is independently associated with 20-year incidence of cardiovascular disease: findings from the ATTICA cohort study (2002-2022).International journal of obesity (2005) · 2026Article
- Association of HDL-C Levels with Stroke and All-cause Mortality: A Prospective Cohort Study from the CHARLS.Brain and behavior · 2026Article
- Defective high-density lipoprotein lipoprotection in type 2 diabetes during acute myocardial infarction is rescued by apolipoprotein M/sphingosine-1-phosphate loading.Diabetes, obesity & metabolism · 2026Article
- Burden of premature atherosclerotic cardiovascular disease and its risk factors among young and middle-aged adults in primary care clinics of Karachi, Pakistan.Journal of health, population, and nutrition · 2026Article
- An Overview of the Effects of Exercise on Viral Infection in Obesity: Recent Advances and Potential Mechanisms.Applied biochemistry and biotechnology · 2026Review
- Dose-response relationships of normal blood lipid levels in metabolic and endocrine diseases: mechanistic similarities, differences, and functional insights.Frontiers in endocrinology · 2026Review
- The triglyceride-glucose index can indicate lipid and atherogenic alterations in adolescents, regardless of excess weight.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2026Article
- Characterizing the Lipid Profile in Patients with Vertebral or Hip Fragility Fractures: A Hospital-Based Descriptive Study.Journal of clinical medicine · 2025Article
- HDL Function Versus Small Dense LDL: Cardiovascular Benefits and Implications.Journal of clinical medicine · 2025Review
- HDL-Cholesterol and Triglycerides Dynamics: Essential Players in Metabolic Syndrome.Antioxidants (Basel, Switzerland) · 2025Review
- Associations of excessive gestational weight gain with changes in components of maternal reverse cholesterol transport and neonatal outcomes.Scientific reports · 2025Article
- Interaction of genetics risk score and fatty acids quality indices on healthy and unhealthy obesity phenotype.BMC medical genomics · 2025Article
- Effect ofCurrent therapeutic research, clinical and experimental · 2025Article
- U-shaped association of uric acid to HDL cholesterol ratio (UHR) with ALL-cause and cardiovascular mortality in diabetic patients: NHANES 1999-2018.BMC cardiovascular disorders · 2024Article
- Epigenome-wide mediation analysis of the relationship between psychosocial stress and cardiometabolic risk factors in the Health and Retirement Study (HRS).Clinical epigenetics · 2024Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundObesity increases the risk of coronary heart disease, partly due to its strong association with atherogenic dyslipidemia, characterized by high triglycerides and low high-density lipoprotein (HDL) cholesterol levels. Functional impairment of HDL may contribute to the increased cardiovascular mortality, but the effect of obesity on composition, structure, and function of HDL is not well understood
resultsObesity (body mass index (BMI) ≥ 30) was associated with noticeable changes in LCAT and CETP activities and altered HDL composition, such as decreased apolipoprotein A-I, cholesterol, and phospholipid content, while pro-inflammatory HDL serum amyloid a content was increased. We observed a marked shift towards smaller HDL subclasses in obesity linked to lower anti-oxidative capacity of serum. LCAT activity, HDL subclass distribution, and HDL-cholesterol were associated with soluble leptin receptor, adiponectin, and liver enzyme activities. Of note, most of these alterations were only seen in obese women but not in overweight women.
conclusionsObesity markedly affects HDL metabolism, composition, and subclass distribution linked to changes in liver and adipose tissue. HDL dysfunction may contribute to increased cardiovascular risk in obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.