ReviewBrain sciences2021
Presenting Psychiatric and Neurological Symptoms and Signs of Brain Tumors before Diagnosis: A Systematic Review.
Review in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroimaging Insights into the Public Health Burden of Neuropsychiatric Disorders: A Systematic Review of Electroencephalography-Based Cognitive Biomarkers.Medicina (Kaunas, Lithuania) · 2025Pooled it
- The promising role of cathepsins as biomarkers and therapeutic targets in glioblastoma.Discover oncology · 2026Review
- Somatostatin receptor PET in meningioma: diagnosis, therapy, and surveillance.Nuclear medicine communications · 2026Review
- Cerebellar pilocytic astrocytoma in a patient with autism spectrum disorder and psychotic symptoms: a case report.BMC psychiatry · 2025Article
- Behavioral Changes as the Initial Presentation of Primary Central Nervous System Lymphoma: A Case Report.Cureus · 2025Article
- Brain Tumors, AI and Psychiatry: Predicting Tumor-Associated Psychiatric Syndromes with Machine Learning and Biomarkers.International journal of molecular sciences · 2025Review
- The impact of sociodemographic background on clinical presentation of high-grade gliomas: a multi-institutional retrospective analysis.Journal of neuro-oncology · 2025Article
- Rapid resolution of depression and epilepsy following resection of a septal region tumor: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Neurological Conundrums: A Case Series on Brain Tumors Masquerading as Psychiatric Disorders.Indian journal of psychological medicine · 2025Article
- Avoidant/restrictive food intake disorder-like syndrome and cerebellar tumor in an adolescent: a case report.Journal of eating disorders · 2025Article
- Editorial: AI and machine learning application for neurological disorders and diagnosis.Frontiers in human neuroscience · 2025Article
- 'Beyond the blues': A case report on depression as initial presentation of lung cancer with brain metastasis.Journal of education and health promotion · 2025Article
- The Neural Frontier of Future Medical Imaging: A Review of Deep Learning for Brain Tumor Detection.Journal of imaging · 2024Review
- Why do patients with cancer die?Nature reviews. Cancer · 2024Review
- Diagnosing Progression in Glioblastoma-Tackling a Neuro-Oncology Problem Using Artificial-Intelligence-Derived Volumetric Change over Time on Magnetic Resonance Imaging to Examine Progression-Free Survival in Glioblastoma.Diagnostics (Basel, Switzerland) · 2024Article
- A Von Hippel-Lindau Syndrome Case Diagnosed While Hospitalized for Major Depression.Psychiatry and clinical psychopharmacology · 2024Article
- The gut-brain-axis: A positive relationship between gut microbial dysbiosis and glioblastoma brain tumour.Heliyon · 2024Article
- Patients With Hemangioblastoma: Mood Disorders and Sleep Quality.Brain tumor research and treatment · 2024Article
- Artificial intelligence in neuro-oncology: advances and challenges in brain tumor diagnosis, prognosis, and precision treatment.NPJ precision oncology · 2024Review
- Psychiatric presentation in undiagnosed intracranial space-occupying lesions: A case series.Industrial psychiatry journal · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Brain tumors can present with various psychiatric symptoms, with or without neurological symptoms, an aspect that complicates the clinical picture. However, no systematic description of symptoms that should prompt a neurological investigation has been provided. This review aims to summarize available case reports describing patients with brain tumors showing psychiatric symptoms before brain tumor diagnosis, in order to provide a comprehensive description of these symptoms as well as their potential relationship with delay in the diagnosis. A systematic literature review on case reports of brain tumors and psychiatric symptoms from 1970 to 2020 was conducted on PubMed, Ovid, Psych Info, and MEDLINE. Exclusion criteria comprised tumors not included in the World Health Organization (WHO) Classification 4th edition and cases in which psychiatric symptoms were absent or followed the diagnosis. A total of 165 case reports were analyzed. In a subset of patients with brain tumors, psychiatric symptoms can be the only manifestation or precede focal neurological signs by months or even years. The appearance of focal or generalized neurological symptoms after, rather than along with, psychiatric symptoms was associated with a significant delay in the diagnosis in adults. A timely assessment of psychiatric symptoms might help to improve early diagnosis of brain tumors.
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Registered trials
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