Evidence map›Paper›PMID 33673426›Full record

ArticleInternational journal of molecular sciences2021

Human Herpesvirus-6 and -7 in the Brain Microenvironment of Persons with Neurological Pathology and Healthy People.

Sandra Skuja, Simons Svirskis, Modra Murovska

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sandra SkujaInstitute of Anatomy and Anthropology, Rīga Stradiņš University, Kronvalda blvd 9, LV-1010 Rīga, Latvia.ORCID 0000-0002-3589-9429
Simons SvirskisInstitute of Microbiology and Virology, Rīga Stradiņš University, Rātsupītes str. 5, LV-1067 Rīga, Latvia.ORCID 0000-0001-6889-6390
Modra MurovskaInstitute of Microbiology and Virology, Rīga Stradiņš University, Rātsupītes str. 5, LV-1067 Rīga, Latvia.ORCID 0000-0003-0971-1784
Riga Stradiņš University · LV

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During persistent human beta-herpesvirus (HHV) infection, clinical manifestations may not appear. However, the lifelong influence of HHV is often associated with pathological changes in the central nervous system. Herein, we evaluated possible associations between immunoexpression of HHV-6, -7, and cellular immune response across different brain regions. The study aimed to explore HHV-6, -7 infection within the cortical lobes in cases of unspecified encephalopathy (UEP) and nonpathological conditions. We confirmed the presence of viral DNA by nPCR and viral antigens by immunohistochemistry. Overall, we have shown a significant increase (

Indexed as

Herpesvirus 6, HumanHerpesvirus 7, HumanImmunity, CellularAdultAgedAntigens, ViralAstrocytesBrainBrain DiseasesEndothelial CellsFemaleHumansImmunohistochemistryMaleMiddle AgedNeurogliaAntigens, Viralfrontal lobehuman herpesvirus 6human herpesvirus 7immune responseimmunohistochemistryPCRtemporal lobe

Identifiers

PMID33673426
PMCPMC7956495
OpenAlexW3133781513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.