Evidence map›Paper›PMID 33673350›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Biological Profiling of Semisynthetic C19-Functionalized Ferruginol and Sugiol Analogues.

Miguel A González-Cardenete, Fatima Rivas, Rachel Basset, Marco Stadler, Steffen Hering, José M Padrón, Ramón J Zaragozá, María Auxiliadora Dea-Ayuela

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Abietane Diterpenoids from the Hairy Roots ofMolecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Miguel A González-CardeneteInstituto de Tecnología Química (UPV-CSIC), Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas, Avda. de los Naranjos s/n, 46022 Valencia, Spain.ORCID 0000-0002-8762-0426
Fatima RivasDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-3643-2035
Rachel BassetDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Marco StadlerDepartment of Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.
Steffen HeringDepartment of Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.
José M PadrónBioLab, Instituto Universitario de Bio-Orgánica "Antonio González" (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sanchez 2, 38200 La Laguna, Spain.ORCID 0000-0001-6268-6552
Ramón J ZaragozáDepartamento de Química Orgánica, Universidad de Valencia, Dr. Moliner 50, 46100 Burjassot, Spain.
María Auxiliadora Dea-AyuelaDepartamento de Farmacia, Facultad Ciencias de la Salud, Universidad CEU Cardenal Herrera, C/Ramón y Cajal s/n, 46115 Alfara del Patriarca, Spain.

Funding

Austrian Science Fund FWF W 1232Santander Bank-CEU-University CEU-UCH - Banco Santander 2017-2018Spanish Ministry of Science PGC2018-094503-B-C22Spanish National Research Council 201680I008
6 · The paper itself

Abstract

The abietane-type diterpenoids are significant bioactive compounds exhibiting a varied range of pharmacological properties. In this study, the first synthesis and biological investigation of the new abietane-diterpenoid (+)-4-epi-liquiditerpenoid acid (8a) together with several of its analogs are reported. The compounds were generated from the readily available methyl callitrisate (7), which was obtained from callitrisic acid present in Moroccan Sandarac resin. A biological evaluation was conducted to determine the effects of the different functional groups present in these molecules, providing basic structure-activity relationship (SAR) elements. In particular, the ferruginol and sugiol analogs compounds

Indexed as

abietaneantimalarial activityantiproliferative activitycallitrisic acidditerpenoidGABAA receptor modulators

Identifiers

PMID33673350
PMCPMC7918733

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.