Evidence map›Paper›PMID 33673278›Full record

ArticleInternational journal of molecular sciences2021

Interspecific Variation in One-Carbon Metabolism within the Ovarian Follicle, Oocyte, and Preimplantation Embryo: Consequences for Epigenetic Programming of DNA Methylation.

Constance E Clare, Valerie Pestinger, Wing Yee Kwong, Desmond A R Tutt, Juan Xu, Helen M Byrne, David A Barrett, Richard D Emes, Kevin D Sinclair

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Constance E ClareSchools of Biosciences and Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire LE12 5RD, UK.
Valerie PestingerSchools of Biosciences and Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire LE12 5RD, UK.
Wing Yee KwongSchools of Biosciences and Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire LE12 5RD, UK.
Desmond A R TuttSchools of Biosciences and Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire LE12 5RD, UK.
Juan XuSchools of Biosciences and Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire LE12 5RD, UK.
Helen M ByrneMathematical Institute, University of Oxford, Woodstock Road, Oxford OX2 6GG, UK.
David A BarrettCentre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
Richard D EmesSchools of Biosciences and Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire LE12 5RD, UK.ORCID 0000-0001-6855-5481
Kevin D SinclairSchools of Biosciences and Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire LE12 5RD, UK.ORCID 0000-0002-6375-215X
University of Nottingham · GBUniversity of Oxford · GB

Funding

Biotechnology and Biological Sciences Research Council BB/K017810/1Biotechnology and Biological Sciences Research Council BB/R007985/1
6 · The paper itself

Abstract

One-carbon (1C) metabolism provides methyl groups for the synthesis and/or methylation of purines and pyrimidines, biogenic amines, proteins, and phospholipids. Our understanding of how 1C pathways operate, however, pertains mostly to the (rat) liver. Here we report that transcripts for all bar two genes (i.e.,

Indexed as

DNA MethylationEpigenesis, GeneticAnimalsBlastocystCarbonCattleFemaleGranulosa CellsHep G2 CellsHumansOocytesRatsSwineTheca CellsCarbonAssisted Reproduction Technologies (ART)DNA methylationembryoEpigeneticsgenomic imprintingmethionineone-carbon metabolism

Identifiers

PMID33673278
PMCPMC7918761
OpenAlexW3129679118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.